Search Results

Overview

Uniprot IDP02549
Protein NameSpectrin alpha chain, erythrocytic 1
Gene NameSPTA1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
2040 EKQLPLQKAEDLFVE

Function

Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane

Protein Sequence

10 MEQFPKETVV 20 ESSGPKVLET 30 AEEIQERRQE 40 VLTRYQSFKE 50 RVAERGQKLE 60 DSYHLQVFKR 70 DADDLGKWIM 80 EKVNILTDKS 90 YEDPTNIQGK 100 YQKHQSLEAE 110 VQTKSRLMSE 120 LEKTREERFT 130 MGHSAHEETK 140 AHIEELRHLW 150 DLLLELTLEK 160 GDQLLRALKF 170 QQYVQECADI 180 LEWIGDKEAI 190 ATSVELGEDW 200 ERTEVLHKKF 210 EDFQVELVAK 220 EGRVVEVNQY 230 ANECAEENHP 240 DLPLIQSKQN 250 EVNAAWERLR 260 GLALQRQKAL 270 SNAANLQRFK 280 RDVTEAIQWI 290 KEKEPVLTSE 300 DYGKDLVASE 310 GLFHSHKGLE 320 RNLAVMSDKV 330 KELCAKAEKL 340 TLSHPSDAPQ 350 IQEMKEDLVS 360 SWEHIRALAT 370 SRYEKLQATY 380 WYHRFSSDFD 390 ELSGWMNEKT 400 AAINADELPT 410 DVAGGEVLLD 420 RHQQHKHEID 430 SYDDRFQSAD 440 ETGQDLVNAN 450 HEASDEVREK 460 MEILDNNWTA 470 LLELWDERHR 480 QYEQCLDFHL 490 FYRDSEQVDS 500 WMSRQEAFLE 510 NEDLGNSLGS 520 AEALLQKHED 530 FEEAFTAQEE 540 KIITVDKTAT 550 KLIGDDHYDS 560 ENIKAIRDGL 570 LARRDALREK 580 AATRRRLLKE 590 SLLLQKLYED 600 SDDLKNWINK 610 KKKLADDEDY 620 KDIQNLKSRV 630 QKQQVFEKEL 640 AVNKTQLENI 650 QKTGQEMIEG 660 GHYASDNVTT 670 RLSEVASLWE 680 ELLEATKQKG 690 TQLHEANQQL 700 QFENNAEDLQ 710 RWLEDVEWQV 720 TSEDYGKGLA 730 EVQNRLRKHG 740 LLESAVAARQ 750 DQVDILTDLA 760 AYFEEIGHPD 770 SKDIRARQES 780 LVCRFEALKE 790 PLATRKKKLL 800 DLLHLQLICR 810 DTEDEEAWIQ 820 ETEPSATSTY 830 LGKDLIASKK 840 LLNRHRVILE 850 NIASHEPRIQ 860 EITERGNKMV 870 EEGHFAAEDV 880 ASRVKSLNQN 890 MESLRARAAR 900 RQNDLEANVQ 910 FQQYLADLHE 920 AETWIREKEP 930 IVDNTNYGAD 940 EEAAGALLKK 950 HEAFLLDLNS 960 FGDSMKALRN 970 QANACQQQQA 980 APVEGVAGEQ 990 RVMALYDFQA 1000 RSPREVTMKK 1010 GDVLTLLSSI 1020 NKDWWKVEAA 1030 DHQGIVPAVY 1040 VRRLAHDEFP 1050 MLPQRRREEP 1060 GNITQRQEQI 1070 ENQYRSLLDR 1080 AEERRRRLLQ 1090 RYNEFLLAYE 1100 AGDMLEWIQE 1110 KKAENTGVEL 1120 DDVWELQKKF 1130 DEFQKDLNTN 1140 EPRLRDINKV 1150 ADDLLFEGLL 1160 TPEGAQIRQE 1170 LNSRWGSLQR 1180 LADEQRQLLG 1190 SAHAVEVFHR 1200 EADDTKEQIE 1210 KKCQALSAAD 1220 PGSDLFSVQA 1230 LQRRHEGFER 1240 DLVPLGDKVT 1250 ILGETAERLS 1260 ESHPDATEDL 1270 QRQKMELNEA 1280 WEDLQGRTKD 1290 RKESLNEAQK 1300 FYLFLSKARD 1310 LQNWISSIGG 1320 MVSSQELAED 1330 LTGIEILLER 1340 HQEHRADMEA 1350 EAPTFQALED 1360 FSAELIDSGH 1370 HASPEIEKKL 1380 QAVKLERDDL 1390 EKAWEKRKKI 1400 LDQCLELQMF 1410 QGNCDQVESW 1420 MVARENSLRS 1430 DDKSSLDSLE 1440 ALMKKRDDLD 1450 KAITAQEGKI 1460 TDLEHFAESL 1470 IADEHYAKEE 1480 IATRLQRVLD 1490 RWKALKAQLI 1500 DERTKLGDYA 1510 NLKQFYRDLE 1520 ELEEWISEML 1530 PTACDESYKD 1540 ATNIQRKYLK 1550 HQTFAHEVDG 1560 RSEQVHGVIN 1570 LGNSLIECSA 1580 CDGNEEAMKE 1590 QLEQLKEHWD 1600 HLLERTNDKG 1610 KKLNEASRQQ 1620 RFNTSIRDFE 1630 FWLSEAETLL 1640 AMKDQARDLA 1650 SAGNLLKKHQ 1660 LLEREMLARE 1670 DALKDLNTLA 1680 EDLLSSGTFN 1690 VDQIVKKKDN 1700 VNKRFLNVQE 1710 LAAAHHEKLK 1720 EAYALFQFFQ 1730 DLDDEESWIE 1740 EKLIRVSSQD 1750 YGRDLQGVQN 1760 LLKKHKRLEG 1770 ELVAHEPAIQ 1780 NVLDMAEKLK 1790 DKAAVGQEEI 1800 QLRLAQFVEH 1810 WEKLKELAKA 1820 RGLKLEESLE 1830 YLQFMQNAEE 1840 EEAWINEKNA 1850 LAVRGDCGDT 1860 LAATQSLLMK 1870 HEALENDFAV 1880 HETRVQNVCA 1890 QGEDILNKVL 1900 QEESQNKEIS 1910 SKIEALNEKT 1920 PSLAKAIAAW 1930 KLQLEDDYAF 1940 QEFNWKADVV 1950 EAWIADKETS 1960 LKTNGNGADL 1970 GDFLTLLAKQ 1980 DTLDASLQSF 1990 QQERLPEITD 2000 LKDKLISAQH 2010 NQSKAIEERY 2020 AALLKRWEQL 2030 LEASAVHRQK 2040 LLEKQLPLQK 2050 AEDLFVEFAH 2060 KASALNNWCE 2070 KMEENLSEPV 2080 HCVSLNEIRQ 2090 LQKDHEDFLA 2100 SLARAQADFK 2110 CLLELDQQIK 2120 ALGVPSSPYT 2130 WLTVEVLERT 2140 WKHLSDIIEE 2150 REQELQKEEA 2160 RQVKNFEMCQ 2170 EFEQNASTFL 2180 QWILETRAYF 2190 LDGSLLKETG 2200 TLESQLEANK 2210 RKQKEIQAMK 2220 RQLTKIVDLG 2230 DNLEDALILD 2240 IKYSTIGLAQ 2250 QWDQLYQLGL 2260 RMQHNLEQQI 2270 QAKDIKGVSE 2280 ETLKEFSTIY 2290 KHFDENLTGR 2300 LTHKEFRSCL 2310 RGLNYYLPMV 2320 EEDEHEPKFE 2330 KFLDAVDPGR 2340 KGYVSLEDYT 2350 AFLIDKESEN 2360 IKSSDEIENA 2370 FQALAEGKSY 2380 ITKEDMKQAL 2390 TPEQVSFCAT 2400 HMQQYMDPRG 2410 RSHLSGYDYV GFTNSYFGN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0030424 axon
Cellular Component GO:0030054 cell junction
Cellular Component GO:0042995 cell projection
Cellular Component GO:0030864 cortical actin cytoskeleton
Cellular Component GO:0032437 cuticular plate
Cellular Component GO:0009898 cytoplasmic side of plasma membrane
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0008091 spectrin
Cellular Component GO:0014731 spectrin-associated cytoskeleton
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0005200 structural constituent of cytoskeleton
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0051693 actin filament capping
Biological Process GO:0007015 actin filament organization
Biological Process GO:0008360 regulation of cell shape

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.