Search Results
Overview
| Uniprot ID | P02647 |
|---|---|
| Protein Name | Apolipoprotein A-I |
| Gene Name | APOA1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 101 | EFWDNLEKETEGLRQ |
| 118 | SKDLEEVKAKVQPYL |
| 120 | DLEEVKAKVQPYLDD |
| 130 | PYLDDFQKKWQEEME |
| 131 | YLDDFQKKWQEEMEL |
| 142 | EMELYRQKVEPLRAE |
| 157 | LQEGARQKLHELQEK |
| 164 | KLHELQEKLSPLGEE |
| 206 | AARLEALKENGGARL |
| 219 | RLAEYHAKATEHLST |
| 230 | HLSTLSEKAKPALED |
| 232 | STLSEKAKPALEDLR |
| 36 | QSPWDRVKDLATVYV |
| 47 | TVYVDVLKDSGRDYV |
| 64 | FEGSALGKQLNLKLL |
| 69 | LGKQLNLKLLDNWDS |
| 83 | SVTSTFSKLREQLGP |
Function
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility
Protein Sequence
10
MKAAVLTLAV
20
LFLTGSQARH
30
FWQQDEPPQS
40
PWDRVKDLAT
50
VYVDVLKDSG
60
RDYVSQFEGS
70
ALGKQLNLKL
80
LDNWDSVTST
90
FSKLREQLGP
100
VTQEFWDNLE
110
KETEGLRQEM
120
SKDLEEVKAK
130
VQPYLDDFQK
140
KWQEEMELYR
150
QKVEPLRAEL
160
QEGARQKLHE
170
LQEKLSPLGE
180
EMRDRARAHV
190
DALRTHLAPY
200
SDELRQRLAA
210
RLEALKENGG
220
ARLAEYHAKA
230
TEHLSTLSEK
240
AKPALEDLRQ
250
GLLPVLESFK
260
VSFLSALEEY
TKKLNTQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0072562 | blood microparticle |
| Cellular Component | GO:0042627 | chylomicron |
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0030139 | endocytic vesicle |
| Cellular Component | GO:0071682 | endocytic vesicle lumen |
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:1903561 | extracellular vesicle |
| Cellular Component | GO:0034364 | high-density lipoprotein particle |
| Cellular Component | GO:0034362 | low-density lipoprotein particle |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0034774 | secretory granule lumen |
| Cellular Component | GO:0034366 | spherical high-density lipoprotein particle |
| Cellular Component | GO:0034361 | very-low-density lipoprotein particle |
| Molecular Function | GO:0001540 | amyloid-beta binding |
| Molecular Function | GO:0034191 | apolipoprotein A-I receptor binding |
| Molecular Function | GO:0034190 | apolipoprotein receptor binding |
| Molecular Function | GO:0045499 | chemorepellent activity |
| Molecular Function | GO:0015485 | cholesterol binding |
| Molecular Function | GO:0120020 | cholesterol transfer activity |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0031072 | heat shock protein binding |
| Molecular Function | GO:0008035 | high-density lipoprotein particle binding |
| Molecular Function | GO:0070653 | high-density lipoprotein particle receptor binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity |
| Molecular Function | GO:0005543 | phospholipid binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0048018 | receptor ligand activity |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Biological Process | GO:0055090 | acylglycerol homeostasis |
| Biological Process | GO:0034205 | amyloid-beta formation |
| Biological Process | GO:0071402 | cellular response to lipoprotein particle stimulus |
| Biological Process | GO:0033344 | cholesterol efflux |
| Biological Process | GO:0042632 | cholesterol homeostasis |
| Biological Process | GO:0070508 | cholesterol import |
| Biological Process | GO:0008203 | cholesterol metabolic process |
| Biological Process | GO:0030301 | cholesterol transport |
| Biological Process | GO:0007186 | G protein-coupled receptor signaling pathway |
| Biological Process | GO:0034380 | high-density lipoprotein particle assembly |
| Biological Process | GO:0034384 | high-density lipoprotein particle clearance |
| Biological Process | GO:0034375 | high-density lipoprotein particle remodeling |
| Biological Process | GO:0007229 | integrin-mediated signaling pathway |
| Biological Process | GO:0042157 | lipoprotein metabolic process |
| Biological Process | GO:0050919 | negative chemotaxis |
| Biological Process | GO:0060354 | negative regulation of cell adhesion molecule production |
| Biological Process | GO:0002719 | negative regulation of cytokine production involved in immune response |
| Biological Process | GO:0034115 | negative regulation of heterotypic cell-cell adhesion |
| Biological Process | GO:0050728 | negative regulation of inflammatory response |
| Biological Process | GO:0032691 | negative regulation of interleukin-1 beta production |
| Biological Process | GO:0060761 | negative regulation of response to cytokine stimulus |
| Biological Process | GO:0010804 | negative regulation of tumor necrosis factor-mediated signaling pathway |
| Biological Process | GO:0010903 | negative regulation of very-low-density lipoprotein particle remodeling |
| Biological Process | GO:0018206 | peptidyl-methionine modification |
| Biological Process | GO:0006656 | phosphatidylcholine biosynthetic process |
| Biological Process | GO:0033700 | phospholipid efflux |
| Biological Process | GO:0055091 | phospholipid homeostasis |
| Biological Process | GO:0010875 | positive regulation of cholesterol efflux |
| Biological Process | GO:0090205 | positive regulation of cholesterol metabolic process |
| Biological Process | GO:0050766 | positive regulation of phagocytosis |
| Biological Process | GO:1902995 | positive regulation of phospholipid efflux |
| Biological Process | GO:0035025 | positive regulation of Rho protein signal transduction |
| Biological Process | GO:0051496 | positive regulation of stress fiber assembly |
| Biological Process | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading |
| Biological Process | GO:0018158 | protein oxidation |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0032489 | regulation of Cdc42 protein signal transduction |
| Biological Process | GO:0043691 | reverse cholesterol transport |
| Biological Process | GO:0070328 | triglyceride homeostasis |
| Biological Process | GO:0051180 | vitamin transport |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.
[3] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.