Search Results
Overview
| Uniprot ID | P02650 |
|---|---|
| Protein Name | Apolipoprotein E |
| Gene Name | Apoe |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 173 | QKRLAVYKAGAQEGA |
| 252 | QMEEVRSKMEEQTQQ |
Function
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL). It also binds a wide range of cellular receptors including the LDL receptor/LDLR and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles. Finally, APOE also has a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells
Protein Sequence
10
MKALWALLLV
20
PLLTGCLAEG
30
ELEVTDQLPG
40
QSDQPWEQAL
50
NRFWDYLRWV
60
QTLSDQVQEE
70
LQSSQVTQEL
80
TVLMEDTMTE
90
VKAYKKELEE
100
QLGPVAEETR
110
ARLAKEVQAA
120
QARLGADMED
130
LRNRLGQYRN
140
EVNTMLGQST
150
EELRSRLSTH
160
LRKMRKRLMR
170
DADDLQKRLA
180
VYKAGAQEGA
190
ERGVSAIRER
200
LGPLVEQGRQ
210
RTANLGAGAA
220
QPLRDRAQAL
230
SDRIRGRLEE
240
VGNQARDRLE
250
EVREQMEEVR
260
SKMEEQTQQI
270
RLQAEIFQAR
280
IKGWFEPLVE
290
DMQRQWANLM
300
EKIQASVATN
310
SIASTTVPLE
NQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0042627 | chylomicron |
| Cellular Component | GO:0034360 | chylomicron remnant |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0034365 | discoidal high-density lipoprotein particle |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:1903561 | extracellular vesicle |
| Cellular Component | GO:0031232 | extrinsic component of external side of plasma membrane |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0034364 | high-density lipoprotein particle |
| Cellular Component | GO:0034363 | intermediate-density lipoprotein particle |
| Cellular Component | GO:0005770 | late endosome |
| Cellular Component | GO:1990777 | lipoprotein particle |
| Cellular Component | GO:0034362 | low-density lipoprotein particle |
| Cellular Component | GO:0042470 | melanosome |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0097487 | multivesicular body, internal vesicle |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0005635 | nuclear envelope |
| Cellular Component | GO:0043083 | synaptic cleft |
| Cellular Component | GO:0034361 | very-low-density lipoprotein particle |
| Molecular Function | GO:0001540 | amyloid-beta binding |
| Molecular Function | GO:0016209 | antioxidant activity |
| Molecular Function | GO:0120020 | cholesterol transfer activity |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0043395 | heparan sulfate proteoglycan binding |
| Molecular Function | GO:0008201 | heparin binding |
| Molecular Function | GO:0046848 | hydroxyapatite binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0008289 | lipid binding |
| Molecular Function | GO:0005319 | lipid transporter activity |
| Molecular Function | GO:0071813 | lipoprotein particle binding |
| Molecular Function | GO:0050750 | low-density lipoprotein particle receptor binding |
| Molecular Function | GO:0046911 | metal chelating activity |
| Molecular Function | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity |
| Molecular Function | GO:0005543 | phospholipid binding |
| Molecular Function | GO:0046983 | protein dimerization activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0048018 | receptor ligand activity |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Molecular Function | GO:0048156 | tau protein binding |
| Molecular Function | GO:0070326 | very-low-density lipoprotein particle receptor binding |
| Biological Process | GO:0055090 | acylglycerol homeostasis |
| Biological Process | GO:0097113 | AMPA glutamate receptor clustering |
| Biological Process | GO:0042982 | amyloid precursor protein metabolic process |
| Biological Process | GO:0060840 | artery development |
| Biological Process | GO:0048844 | artery morphogenesis |
| Biological Process | GO:0001568 | blood vessel development |
| Biological Process | GO:0055074 | calcium ion homeostasis |
| Biological Process | GO:0071397 | cellular response to cholesterol |
| Biological Process | GO:0071361 | cellular response to ethanol |
| Biological Process | GO:0071363 | cellular response to growth factor stimulus |
| Biological Process | GO:0071347 | cellular response to interleukin-1 |
| Biological Process | GO:0071402 | cellular response to lipoprotein particle stimulus |
| Biological Process | GO:0006707 | cholesterol catabolic process |
| Biological Process | GO:0033344 | cholesterol efflux |
| Biological Process | GO:0042632 | cholesterol homeostasis |
| Biological Process | GO:0008203 | cholesterol metabolic process |
| Biological Process | GO:0034382 | chylomicron remnant clearance |
| Biological Process | GO:0072359 | circulatory system development |
| Biological Process | GO:0055089 | fatty acid homeostasis |
| Biological Process | GO:0006631 | fatty acid metabolic process |
| Biological Process | GO:0007186 | G protein-coupled receptor signaling pathway |
| Biological Process | GO:0010467 | gene expression |
| Biological Process | GO:0034380 | high-density lipoprotein particle assembly |
| Biological Process | GO:0034384 | high-density lipoprotein particle clearance |
| Biological Process | GO:0034375 | high-density lipoprotein particle remodeling |
| Biological Process | GO:0044794 | host-mediated activation of viral process |
| Biological Process | GO:0071831 | intermediate-density lipoprotein particle clearance |
| Biological Process | GO:0006874 | intracellular calcium ion homeostasis |
| Biological Process | GO:0055088 | lipid homeostasis |
| Biological Process | GO:0006629 | lipid metabolic process |
| Biological Process | GO:0006869 | lipid transport |
| Biological Process | GO:0010877 | lipid transport involved in lipid storage |
| Biological Process | GO:0042158 | lipoprotein biosynthetic process |
| Biological Process | GO:0042159 | lipoprotein catabolic process |
| Biological Process | GO:0042157 | lipoprotein metabolic process |
| Biological Process | GO:0035641 | locomotory exploration behavior |
| Biological Process | GO:0015909 | long-chain fatty acid transport |
| Biological Process | GO:0007616 | long-term memory |
| Biological Process | GO:0034374 | low-density lipoprotein particle remodeling |
| Biological Process | GO:0051651 | maintenance of location in cell |
| Biological Process | GO:0032438 | melanosome organization |
| Biological Process | GO:1905907 | negative regulation of amyloid fibril formation |
| Biological Process | GO:1902430 | negative regulation of amyloid-beta formation |
| Biological Process | GO:0030195 | negative regulation of blood coagulation |
| Biological Process | GO:0043537 | negative regulation of blood vessel endothelial cell migration |
| Biological Process | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| Biological Process | GO:0045541 | negative regulation of cholesterol biosynthetic process |
| Biological Process | GO:0090370 | negative regulation of cholesterol efflux |
| Biological Process | GO:0061000 | negative regulation of dendritic spine development |
| Biological Process | GO:1902951 | negative regulation of dendritic spine maintenance |
| Biological Process | GO:0010596 | negative regulation of endothelial cell migration |
| Biological Process | GO:0001937 | negative regulation of endothelial cell proliferation |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:0050728 | negative regulation of inflammatory response |
| Biological Process | GO:0051055 | negative regulation of lipid biosynthetic process |
| Biological Process | GO:1903001 | negative regulation of lipid transport across blood-brain barrier |
| Biological Process | GO:1900272 | negative regulation of long-term synaptic potentiation |
| Biological Process | GO:0043409 | negative regulation of MAPK cascade |
| Biological Process | GO:0010977 | negative regulation of neuron projection development |
| Biological Process | GO:1902999 | negative regulation of phospholipid efflux |
| Biological Process | GO:0010544 | negative regulation of platelet activation |
| Biological Process | GO:0010642 | negative regulation of platelet-derived growth factor receptor signaling pathway |
| Biological Process | GO:1901627 | negative regulation of postsynaptic membrane organization |
| Biological Process | GO:0051248 | negative regulation of protein metabolic process |
| Biological Process | GO:0050709 | negative regulation of protein secretion |
| Biological Process | GO:0048662 | negative regulation of smooth muscle cell proliferation |
| Biological Process | GO:0090209 | negative regulation of triglyceride metabolic process |
| Biological Process | GO:0031175 | neuron projection development |
| Biological Process | GO:0031102 | neuron projection regeneration |
| Biological Process | GO:0038060 | nitric oxide-cGMP-mediated signaling |
| Biological Process | GO:0097114 | NMDA glutamate receptor clustering |
| Biological Process | GO:0048709 | oligodendrocyte differentiation |
| Biological Process | GO:0014012 | peripheral nervous system axon regeneration |
| Biological Process | GO:0033700 | phospholipid efflux |
| Biological Process | GO:1900223 | positive regulation of amyloid-beta clearance |
| Biological Process | GO:1902004 | positive regulation of amyloid-beta formation |
| Biological Process | GO:0045773 | positive regulation of axon extension |
| Biological Process | GO:0010875 | positive regulation of cholesterol efflux |
| Biological Process | GO:0090205 | positive regulation of cholesterol metabolic process |
| Biological Process | GO:0060999 | positive regulation of dendritic spine development |
| Biological Process | GO:1902952 | positive regulation of dendritic spine maintenance |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0045807 | positive regulation of endocytosis |
| Biological Process | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:0046889 | positive regulation of lipid biosynthetic process |
| Biological Process | GO:1903002 | positive regulation of lipid transport across blood-brain barrier |
| Biological Process | GO:0140077 | positive regulation of lipoprotein transport |
| Biological Process | GO:0032805 | positive regulation of low-density lipoprotein particle receptor catabolic process |
| Biological Process | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis |
| Biological Process | GO:1902998 | positive regulation of neurofibrillary tangle assembly |
| Biological Process | GO:0010976 | positive regulation of neuron projection development |
| Biological Process | GO:0045429 | positive regulation of nitric oxide biosynthetic process |
| Biological Process | GO:1902995 | positive regulation of phospholipid efflux |
| Biological Process | GO:1901631 | positive regulation of presynaptic membrane organization |
| Biological Process | GO:0017038 | protein import |
| Biological Process | GO:0006898 | receptor-mediated endocytosis |
| Biological Process | GO:1905906 | regulation of amyloid fibril formation |
| Biological Process | GO:1902991 | regulation of amyloid precursor protein catabolic process |
| Biological Process | GO:1900221 | regulation of amyloid-beta clearance |
| Biological Process | GO:0042981 | regulation of apoptotic process |
| Biological Process | GO:2000822 | regulation of behavioral fear response |
| Biological Process | GO:0032489 | regulation of Cdc42 protein signal transduction |
| Biological Process | GO:1905890 | regulation of cellular response to very-low-density lipoprotein particle stimulus |
| Biological Process | GO:0090181 | regulation of cholesterol metabolic process |
| Biological Process | GO:0010468 | regulation of gene expression |
| Biological Process | GO:0045088 | regulation of innate immune response |
| Biological Process | GO:0097006 | regulation of plasma lipoprotein particle levels |
| Biological Process | GO:0061136 | regulation of proteasomal protein catabolic process |
| Biological Process | GO:0051246 | regulation of protein metabolic process |
| Biological Process | GO:0043254 | regulation of protein-containing complex assembly |
| Biological Process | GO:0050807 | regulation of synapse organization |
| Biological Process | GO:0090207 | regulation of triglyceride metabolic process |
| Biological Process | GO:0061771 | response to caloric restriction |
| Biological Process | GO:1904421 | response to D-galactosamine |
| Biological Process | GO:0002021 | response to dietary excess |
| Biological Process | GO:0045471 | response to ethanol |
| Biological Process | GO:0032868 | response to insulin |
| Biological Process | GO:0006979 | response to oxidative stress |
| Biological Process | GO:0032526 | response to retinoic acid |
| Biological Process | GO:0034612 | response to tumor necrosis factor |
| Biological Process | GO:0010043 | response to zinc ion |
| Biological Process | GO:0043691 | reverse cholesterol transport |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0070328 | triglyceride homeostasis |
| Biological Process | GO:0006641 | triglyceride metabolic process |
| Biological Process | GO:0071830 | triglyceride-rich lipoprotein particle clearance |
| Biological Process | GO:0042311 | vasodilation |
| Biological Process | GO:0034447 | very-low-density lipoprotein particle clearance |
| Biological Process | GO:0034372 | very-low-density lipoprotein particle remodeling |
| Biological Process | GO:0019068 | virion assembly |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.