Search Results
Overview
| Uniprot ID | P02652 |
|---|---|
| Protein Name | Apolipoprotein A-II |
| Gene Name | APOA2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 51 | YGKDLMEKVKSPELQ |
| 53 | KDLMEKVKSPELQAE |
| 62 | PELQAEAKSYFEKSK |
| 69 | KSYFEKSKEQLTPLI |
| 77 | EQLTPLIKKAGTELV |
Function
May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism
Protein Sequence
10
MKLLAATVLL
20
LTICSLEGAL
30
VRRQAKEPCV
40
ESLVSQYFQT
50
VTDYGKDLME
60
KVKSPELQAE
70
AKSYFEKSKE
80
QLTPLIKKAG
90
TELVNFLSYF
100
VELGTQPATQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0072562 | blood microparticle |
| Cellular Component | GO:0042627 | chylomicron |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0034364 | high-density lipoprotein particle |
| Cellular Component | GO:0034366 | spherical high-density lipoprotein particle |
| Cellular Component | GO:0034361 | very-low-density lipoprotein particle |
| Molecular Function | GO:0034190 | apolipoprotein receptor binding |
| Molecular Function | GO:0015485 | cholesterol binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0031072 | heat shock protein binding |
| Molecular Function | GO:0008035 | high-density lipoprotein particle binding |
| Molecular Function | GO:0070653 | high-density lipoprotein particle receptor binding |
| Molecular Function | GO:0055102 | lipase inhibitor activity |
| Molecular Function | GO:0008289 | lipid binding |
| Molecular Function | GO:0005319 | lipid transporter activity |
| Molecular Function | GO:0031210 | phosphatidylcholine binding |
| Molecular Function | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity |
| Molecular Function | GO:0005543 | phospholipid binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0048018 | receptor ligand activity |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Biological Process | GO:0071402 | cellular response to lipoprotein particle stimulus |
| Biological Process | GO:0033344 | cholesterol efflux |
| Biological Process | GO:0042632 | cholesterol homeostasis |
| Biological Process | GO:0030301 | cholesterol transport |
| Biological Process | GO:0046340 | diacylglycerol catabolic process |
| Biological Process | GO:0034380 | high-density lipoprotein particle assembly |
| Biological Process | GO:0034384 | high-density lipoprotein particle clearance |
| Biological Process | GO:0034375 | high-density lipoprotein particle remodeling |
| Biological Process | GO:0042157 | lipoprotein metabolic process |
| Biological Process | GO:0034374 | low-density lipoprotein particle remodeling |
| Biological Process | GO:0060621 | negative regulation of cholesterol import |
| Biological Process | GO:0032375 | negative regulation of cholesterol transport |
| Biological Process | GO:0002719 | negative regulation of cytokine production involved in immune response |
| Biological Process | GO:0050995 | negative regulation of lipid catabolic process |
| Biological Process | GO:0010903 | negative regulation of very-low-density lipoprotein particle remodeling |
| Biological Process | GO:0018206 | peptidyl-methionine modification |
| Biological Process | GO:0006656 | phosphatidylcholine biosynthetic process |
| Biological Process | GO:0009395 | phospholipid catabolic process |
| Biological Process | GO:0033700 | phospholipid efflux |
| Biological Process | GO:0032757 | positive regulation of interleukin-8 production |
| Biological Process | GO:0050996 | positive regulation of lipid catabolic process |
| Biological Process | GO:0050766 | positive regulation of phagocytosis |
| Biological Process | GO:0018158 | protein oxidation |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0031647 | regulation of protein stability |
| Biological Process | GO:0009749 | response to glucose |
| Biological Process | GO:0043691 | reverse cholesterol transport |
| Biological Process | GO:0006641 | triglyceride metabolic process |
| Biological Process | GO:0034370 | triglyceride-rich lipoprotein particle remodeling |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.
[3] Hu J, Jin Z, Gao Y, Liu Q, Yu Y et al.. Global Profiling of Lactylation Proteomics and Specific Lactylated Site Validation in Rheumatoid Arthritis Patients.. J Proteome Res 24(4):1732-1744. 2025 Apr 4. PMID: 40112136.