Search Results
Overview
| Uniprot ID | P02654 |
|---|---|
| Protein Name | Apolipoprotein C-I |
| Gene Name | APOC1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 47 | FGNTLEDKARELISR |
| 56 | RELISRIKQSELSAK |
| 74 | WFSETFQKVKEKLKI |
Function
Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0042627 | chylomicron |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0034364 | high-density lipoprotein particle |
| Cellular Component | GO:0034361 | very-low-density lipoprotein particle |
| Molecular Function | GO:0005504 | fatty acid binding |
| Molecular Function | GO:0055102 | lipase inhibitor activity |
| Molecular Function | GO:0031210 | phosphatidylcholine binding |
| Molecular Function | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity |
| Molecular Function | GO:0004859 | phospholipase inhibitor activity |
| Biological Process | GO:0033344 | cholesterol efflux |
| Biological Process | GO:0034382 | chylomicron remnant clearance |
| Biological Process | GO:0034375 | high-density lipoprotein particle remodeling |
| Biological Process | GO:0006629 | lipid metabolic process |
| Biological Process | GO:0042157 | lipoprotein metabolic process |
| Biological Process | GO:0032375 | negative regulation of cholesterol transport |
| Biological Process | GO:0045717 | negative regulation of fatty acid biosynthetic process |
| Biological Process | GO:0050995 | negative regulation of lipid catabolic process |
| Biological Process | GO:0045833 | negative regulation of lipid metabolic process |
| Biological Process | GO:0010900 | negative regulation of phosphatidylcholine catabolic process |
| Biological Process | GO:0048261 | negative regulation of receptor-mediated endocytosis |
| Biological Process | GO:0010897 | negative regulation of triglyceride catabolic process |
| Biological Process | GO:0010916 | negative regulation of very-low-density lipoprotein particle clearance |
| Biological Process | GO:0033700 | phospholipid efflux |
| Biological Process | GO:0034369 | plasma lipoprotein particle remodeling |
| Biological Process | GO:0032374 | regulation of cholesterol transport |
| Biological Process | GO:0070328 | triglyceride homeostasis |
| Biological Process | GO:0006641 | triglyceride metabolic process |
| Biological Process | GO:0034379 | very-low-density lipoprotein particle assembly |
| Biological Process | GO:0034447 | very-low-density lipoprotein particle clearance |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.