Search Results
Overview
| Uniprot ID | P02655 |
|---|---|
| Protein Name | Apolipoprotein C-II |
| Gene Name | APOC2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 61 | AAQNLYEKTYLPAVD |
| 70 | YLPAVDEKLRDLYSK |
Function
Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL
Protein Sequence
10
MGTRLLPALF
20
LVLLVLGFEV
30
QGTQQPQQDE
40
MPSPTFLTQV
50
KESLSSYWES
60
AKTAAQNLYE
70
KTYLPAVDEK
80
LRDLYSKSTA
90
AMSTYTGIFT
100
DQVLSVLKGE
E
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0042627 | chylomicron |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0034363 | intermediate-density lipoprotein particle |
| Cellular Component | GO:0034362 | low-density lipoprotein particle |
| Cellular Component | GO:0034366 | spherical high-density lipoprotein particle |
| Cellular Component | GO:0034361 | very-low-density lipoprotein particle |
| Molecular Function | GO:0055102 | lipase inhibitor activity |
| Molecular Function | GO:0008289 | lipid binding |
| Molecular Function | GO:0060230 | lipoprotein lipase activator activity |
| Molecular Function | GO:0140677 | molecular function activator activity |
| Molecular Function | GO:0016004 | phospholipase activator activity |
| Molecular Function | GO:0043274 | phospholipase binding |
| Biological Process | GO:0033344 | cholesterol efflux |
| Biological Process | GO:0042632 | cholesterol homeostasis |
| Biological Process | GO:0034382 | chylomicron remnant clearance |
| Biological Process | GO:0034371 | chylomicron remodeling |
| Biological Process | GO:0034384 | high-density lipoprotein particle clearance |
| Biological Process | GO:0016042 | lipid catabolic process |
| Biological Process | GO:0042159 | lipoprotein catabolic process |
| Biological Process | GO:0032375 | negative regulation of cholesterol transport |
| Biological Process | GO:0045833 | negative regulation of lipid metabolic process |
| Biological Process | GO:0048261 | negative regulation of receptor-mediated endocytosis |
| Biological Process | GO:0010916 | negative regulation of very-low-density lipoprotein particle clearance |
| Biological Process | GO:0033700 | phospholipid efflux |
| Biological Process | GO:0045723 | positive regulation of fatty acid biosynthetic process |
| Biological Process | GO:0060697 | positive regulation of phospholipid catabolic process |
| Biological Process | GO:0010898 | positive regulation of triglyceride catabolic process |
| Biological Process | GO:0010902 | positive regulation of very-low-density lipoprotein particle remodeling |
| Biological Process | GO:0043691 | reverse cholesterol transport |
| Biological Process | GO:0070328 | triglyceride homeostasis |
| Biological Process | GO:0034370 | triglyceride-rich lipoprotein particle remodeling |
| Biological Process | GO:0034372 | very-low-density lipoprotein particle remodeling |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.