Search Results
Overview
| Uniprot ID | P02656 |
|---|---|
| Protein Name | Apolipoprotein C-III |
| Gene Name | APOC3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 44 | KHATKTAKDALSSVQ |
Function
Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma (PubMed:18201179, PubMed:22510806). Plays a multifaceted role in triglyceride homeostasis (PubMed:18201179, PubMed:22510806). Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs) (PubMed:18201179, PubMed:22510806). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors (PubMed:18201179, PubMed:22510806). Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners (PubMed:18408013)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0042627 | chylomicron |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0034363 | intermediate-density lipoprotein particle |
| Cellular Component | GO:0034366 | spherical high-density lipoprotein particle |
| Cellular Component | GO:0034361 | very-low-density lipoprotein particle |
| Molecular Function | GO:0015485 | cholesterol binding |
| Molecular Function | GO:0070653 | high-density lipoprotein particle receptor binding |
| Molecular Function | GO:0055102 | lipase inhibitor activity |
| Molecular Function | GO:0005543 | phospholipid binding |
| Biological Process | GO:0033344 | cholesterol efflux |
| Biological Process | GO:0042632 | cholesterol homeostasis |
| Biological Process | GO:0034382 | chylomicron remnant clearance |
| Biological Process | GO:0007186 | G protein-coupled receptor signaling pathway |
| Biological Process | GO:0034375 | high-density lipoprotein particle remodeling |
| Biological Process | GO:0042157 | lipoprotein metabolic process |
| Biological Process | GO:0060621 | negative regulation of cholesterol import |
| Biological Process | GO:0045717 | negative regulation of fatty acid biosynthetic process |
| Biological Process | GO:0010987 | negative regulation of high-density lipoprotein particle clearance |
| Biological Process | GO:0050995 | negative regulation of lipid catabolic process |
| Biological Process | GO:0045833 | negative regulation of lipid metabolic process |
| Biological Process | GO:0010989 | negative regulation of low-density lipoprotein particle clearance |
| Biological Process | GO:0048261 | negative regulation of receptor-mediated endocytosis |
| Biological Process | GO:0010897 | negative regulation of triglyceride catabolic process |
| Biological Process | GO:0010916 | negative regulation of very-low-density lipoprotein particle clearance |
| Biological Process | GO:0010903 | negative regulation of very-low-density lipoprotein particle remodeling |
| Biological Process | GO:0033700 | phospholipid efflux |
| Biological Process | GO:0032489 | regulation of Cdc42 protein signal transduction |
| Biological Process | GO:0043691 | reverse cholesterol transport |
| Biological Process | GO:0019433 | triglyceride catabolic process |
| Biological Process | GO:0070328 | triglyceride homeostasis |
| Biological Process | GO:0006641 | triglyceride metabolic process |
| Biological Process | GO:0034379 | very-low-density lipoprotein particle assembly |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.
[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.