Search Results

Overview

Uniprot ID	P02671
Protein Name	Fibrinogen alpha chain
Gene Name	FGA
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
100	FEYQKNNKDSHSLTT
148	LKRKVIEKVQHIQLL
157	QHIQLLQKNVRAQLV
167	RAQLVDMKRLEVDID
195	LAREVDLKDYEDQQK
210	QLEQVIAKDLLPSRD
227	HLPLIKMKPVPDLVP
432	RREYHTEKLVTSKGD
437	TEKLVTSKGDKELRT
448	ELRTGKEKVTSGSTT
463	TTRRSCSKTVTKTVI
467	SCSKTVTKTVIGPDG
476	VIGPDGHKEVTKEVV
480	DGHKEVTKEVVTSED
558	SGIFTNTKESSSHHP
581	GKSSSYSKQFTSSTS
599	GDSTFESKSYKMADE
602	TFESKSYKMADEAGS
71	CPSGCRMKGLIDEVN
89	TNRINKLKNSLFEYQ

Function

Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways

Protein Sequence

10 MFSMRIVCLV 20 LSVVGTAWTA 30 DSGEGDFLAE 40 GGGVRGPRVV 50 ERHQSACKDS 60 DWPFCSDEDW 70 NYKCPSGCRM 80 KGLIDEVNQD 90 FTNRINKLKN 100 SLFEYQKNNK 110 DSHSLTTNIM 120 EILRGDFSSA 130 NNRDNTYNRV 140 SEDLRSRIEV 150 LKRKVIEKVQ 160 HIQLLQKNVR 170 AQLVDMKRLE 180 VDIDIKIRSC 190 RGSCSRALAR 200 EVDLKDYEDQ 210 QKQLEQVIAK 220 DLLPSRDRQH 230 LPLIKMKPVP 240 DLVPGNFKSQ 250 LQKVPPEWKA 260 LTDMPQMRME 270 LERPGGNEIT 280 RGGSTSYGTG 290 SETESPRNPS 300 SAGSWNSGSS 310 GPGSTGNRNP 320 GSSGTGGTAT 330 WKPGSSGPGS 340 TGSWNSGSSG 350 TGSTGNQNPG 360 SPRPGSTGTW 370 NPGSSERGSA 380 GHWTSESSVS 390 GSTGQWHSES 400 GSFRPDSPGS 410 GNARPNNPDW 420 GTFEEVSGNV 430 SPGTRREYHT 440 EKLVTSKGDK 450 ELRTGKEKVT 460 SGSTTTTRRS 470 CSKTVTKTVI 480 GPDGHKEVTK 490 EVVTSEDGSD 500 CPEAMDLGTL 510 SGIGTLDGFR 520 HRHPDEAAFF 530 DTASTGKTFP 540 GFFSPMLGEF 550 VSETESRGSE 560 SGIFTNTKES 570 SSHHPGIAEF 580 PSRGKSSSYS 590 KQFTSSTSYN 600 RGDSTFESKS 610 YKMADEAGSE 620 ADHEGTHSTK 630 RGHAKSRPVR 640 DCDDVLQTHP 650 SGTQSGIFNI 660 KLPGSSKIFS 670 VYCDQETSLG 680 GWLLIQQRMD 690 GSLNFNRTWQ 700 DYKRGFGSLN 710 DEGEGEFWLG 720 NDYLHLLTQR 730 GSVLRVELED 740 WAGNEAYAEY 750 HFRVGSEAEG 760 YALQVSSYEG 770 TAGDALIEGS 780 VEEGAEYTSH 790 NNMQFSTFDR 800 DADQWEENCA 810 EVYGGGWWYN 820 NCQAANLNGI 830 YYPGGSYDPR 840 NNSPYEIENG 850 VVWVSFRGAD 860 YSLRAVRMKI RPLVTQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0072562	blood microparticle
Biological Process	GO:0051258	protein polymerization
Biological Process	GO:0065003	protein-containing complex assembly
Biological Process	GO:0051592	response to calcium ion
Cellular Component	GO:0009986	cell surface
Cellular Component	GO:0005783	endoplasmic reticulum
Cellular Component	GO:0005788	endoplasmic reticulum lumen
Cellular Component	GO:0009897	external side of plasma membrane
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0031012	extracellular matrix
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:1903561	extracellular vesicle
Cellular Component	GO:0005577	fibrinogen complex
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0031091	platelet alpha granule
Cellular Component	GO:0031093	platelet alpha granule lumen
Molecular Function	GO:0005201	extracellular matrix structural constituent
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0030674	protein-macromolecule adaptor activity
Molecular Function	GO:0005102	signaling receptor binding
Molecular Function	GO:0005198	structural molecule activity
Biological Process	GO:0002250	adaptive immune response
Biological Process	GO:0072377	blood coagulation, common pathway
Biological Process	GO:0072378	blood coagulation, fibrin clot formation
Biological Process	GO:0007160	cell-matrix adhesion
Biological Process	GO:0042730	fibrinolysis
Biological Process	GO:0043152	induction of bacterial agglutination
Biological Process	GO:0045087	innate immune response
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
Biological Process	GO:0031639	plasminogen activation
Biological Process	GO:0070527	platelet aggregation
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade
Biological Process	GO:0045921	positive regulation of exocytosis
Biological Process	GO:0034116	positive regulation of heterotypic cell-cell adhesion
Biological Process	GO:0090277	positive regulation of peptide hormone secretion
Biological Process	GO:0050714	positive regulation of protein secretion
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading
Biological Process	GO:0045907	positive regulation of vasoconstriction

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.