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Overview

Uniprot IDP02675
Protein NameFibrinogen beta chain
Gene NameFGB
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
163 QKRQKQVKDNENVVN
264 IQPDSSVKPYRVYCD
313 VATNTDGKNYCGLPG
353 DWKGDKVKAHYGGFT
367 TVQNEANKYQISVNK
374 KYQISVNKYRGTAGN
83 AKAAATQKKVERKAP

Function

Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways

Protein Sequence

10 MKRMVSWSFH 20 KLKTMKHLLL 30 LLLCVFLVKS 40 QGVNDNEEGF 50 FSARGHRPLD 60 KKREEAPSLR 70 PAPPPISGGG 80 YRARPAKAAA 90 TQKKVERKAP 100 DAGGCLHADP 110 DLGVLCPTGC 120 QLQEALLQQE 130 RPIRNSVDEL 140 NNNVEAVSQT 150 SSSSFQYMYL 160 LKDLWQKRQK 170 QVKDNENVVN 180 EYSSELEKHQ 190 LYIDETVNSN 200 IPTNLRVLRS 210 ILENLRSKIQ 220 KLESDVSAQM 230 EYCRTPCTVS 240 CNIPVVSGKE 250 CEEIIRKGGE 260 TSEMYLIQPD 270 SSVKPYRVYC 280 DMNTENGGWT 290 VIQNRQDGSV 300 DFGRKWDPYK 310 QGFGNVATNT 320 DGKNYCGLPG 330 EYWLGNDKIS 340 QLTRMGPTEL 350 LIEMEDWKGD 360 KVKAHYGGFT 370 VQNEANKYQI 380 SVNKYRGTAG 390 NALMDGASQL 400 MGENRTMTIH 410 NGMFFSTYDR 420 DNDGWLTSDP 430 RKQCSKEDGG 440 GWWYNRCHAA 450 NPNGRYYWGG 460 QYTWDMAKHG 470 TDDGVVWMNW 480 KGSWYSMRKM 490 SMKIRPFFPQ Q

Gene Ontology

Classification GO ID Description
Cellular Component GO:0072562 blood microparticle
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0009986 cell surface
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0009897 external side of plasma membrane
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:1903561 extracellular vesicle
Cellular Component GO:0005577 fibrinogen complex
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0031091 platelet alpha granule
Cellular Component GO:0031093 platelet alpha granule lumen
Cellular Component GO:0045202 synapse
Molecular Function GO:0005201 extracellular matrix structural constituent
Molecular Function GO:0051087 protein-folding chaperone binding
Molecular Function GO:0005102 signaling receptor binding
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0002250 adaptive immune response
Biological Process GO:0072378 blood coagulation, fibrin clot formation
Biological Process GO:0007160 cell-matrix adhesion
Biological Process GO:0071347 cellular response to interleukin-1
Biological Process GO:0044320 cellular response to leptin stimulus
Biological Process GO:0042730 fibrinolysis
Biological Process GO:0043152 induction of bacterial agglutination
Biological Process GO:0045087 innate immune response
Biological Process GO:2000352 negative regulation of endothelial cell apoptotic process
Biological Process GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
Biological Process GO:0031639 plasminogen activation
Biological Process GO:0070527 platelet aggregation
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0045921 positive regulation of exocytosis
Biological Process GO:0034116 positive regulation of heterotypic cell-cell adhesion
Biological Process GO:0090277 positive regulation of peptide hormone secretion
Biological Process GO:0050714 positive regulation of protein secretion
Biological Process GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
Biological Process GO:0045907 positive regulation of vasoconstriction
Biological Process GO:0051258 protein polymerization
Biological Process GO:0065003 protein-containing complex assembly
Biological Process GO:0051592 response to calcium ion

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.