Overview
| Uniprot ID | P02686 |
|---|
| Protein Name | Myelin basic protein |
|---|
| Gene Name | MBP |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 147 |
PSQRHGSKYLATAST |
| 192 |
APKRGSGKDSHHPAR |
| 209 |
HYGSLPQKSHGRTQD |
| 225 |
NPVVHFFKNIVTPRT |
| 239 |
TPPPSQGKGRGLSLS |
| 269 |
GGRASDYKSAHKGFK |
| 273 |
SDYKSAHKGFKGVDA |
| 276 |
KSAHKGFKGVDAQGT |
| 286 |
DAQGTLSKIFKLGGR |
Function
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation
Protein Sequence
10
MGNHAGKREL
20
NAEKASTNSE
30
TNRGESEKKR
40
NLGELSRTTS
50
EDNEVFGEAD
60
ANQNNGTSSQ
70
DTAVTDSKRT
80
ADPKNAWQDA
90
HPADPGSRPH
100
LIRLFSRDAP
110
GREDNTFKDR
120
PSESDELQTI
130
QEDSAATSES
140
LDVMASQKRP
150
SQRHGSKYLA
160
TASTMDHARH
170
GFLPRHRDTG
180
ILDSIGRFFG
190
GDRGAPKRGS
200
GKDSHHPART
210
AHYGSLPQKS
220
HGRTQDENPV
230
VHFFKNIVTP
240
RTPPPSQGKG
250
RGLSLSRFSW
260
GAEGQRPGFG
270
YGGRASDYKS
280
AHKGFKGVDA
290
QGTLSKIFKL
300
GGRDSRSGSP
MARR
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0071944 |
cell periphery |
| Cellular Component |
GO:0009986 |
cell surface |
| Cellular Component |
GO:0043218 |
compact myelin |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0033269 |
internode region of axon |
| Cellular Component |
GO:0043209 |
myelin sheath |
| Cellular Component |
GO:0043025 |
neuronal cell body |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0032991 |
protein-containing complex |
| Cellular Component |
GO:0045202 |
synapse |
| Molecular Function |
GO:0005516 |
calmodulin binding |
| Molecular Function |
GO:0008289 |
lipid binding |
| Molecular Function |
GO:0002020 |
protease binding |
| Molecular Function |
GO:0019911 |
structural constituent of myelin sheath |
| Biological Process |
GO:0008366 |
axon ensheathment |
| Biological Process |
GO:0007417 |
central nervous system development |
| Biological Process |
GO:0007268 |
chemical synaptic transmission |
| Biological Process |
GO:0006955 |
immune response |
| Biological Process |
GO:0032288 |
myelin assembly |
| Biological Process |
GO:0042552 |
myelination |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.