Search Results
Overview
| Uniprot ID | P02688 |
|---|---|
| Protein Name | Myelin basic protein |
| Gene Name | Mbp |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 100 | HYGSLPQKSQRTQDE |
| 115 | NPVVHFFKNIVTPRT |
| 129 | TPPPSQGKGRGLSLS |
| 14 | PSQRHGSKYLATAST |
| 146 | SWGAEGQKPGFGYGG |
| 159 | GGRASDYKSAHKGFK |
| 163 | SDYKSAHKGFKGAYD |
| 166 | KSAHKGFKGAYDAQG |
| 177 | DAQGTLSKIFKLGGR |
| 59 | APKRGSGKVPWLKQS |
| 64 | SGKVPWLKQSRSPLP |
| 85 | PGLCHMYKDSHTRTT |
Function
Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0071944 | cell periphery |
| Cellular Component | GO:0042995 | cell projection |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0043218 | compact myelin |
| Cellular Component | GO:0033269 | internode region of axon |
| Cellular Component | GO:0043209 | myelin sheath |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0008289 | lipid binding |
| Molecular Function | GO:0002020 | protease binding |
| Molecular Function | GO:0017124 | SH3 domain binding |
| Molecular Function | GO:0019911 | structural constituent of myelin sheath |
| Biological Process | GO:0061024 | membrane organization |
| Biological Process | GO:0032288 | myelin assembly |
| Biological Process | GO:0042552 | myelination |
| Biological Process | GO:0050771 | negative regulation of axonogenesis |
| Biological Process | GO:0070542 | response to fatty acid |
| Biological Process | GO:0046689 | response to mercury ion |
| Biological Process | GO:0032570 | response to progesterone |
| Biological Process | GO:0009636 | response to toxic substance |
| Biological Process | GO:0034612 | response to tumor necrosis factor |
| Biological Process | GO:0007605 | sensory perception of sound |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.