Search Results

Overview

Uniprot IDP02730
Protein NameBand 3 anion transport protein
Gene NameSLC4A1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
353 RYQSSPAKPDSSFYK
743 NALTVMGKASTPGAA
757 AAQIQEVKEQRISGL

Function

Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein (PubMed:10926824, PubMed:14734552, PubMed:1538405, PubMed:16227998, PubMed:20151848, PubMed:24121512, PubMed:28387307, PubMed:35835865). Component of the ankyrin-1 complex of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin (PubMed:1538405, PubMed:20151848, PubMed:35835865). Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine (PubMed:10926824, PubMed:14734552, PubMed:16227998, PubMed:24121512, PubMed:28387307)

Protein Sequence

10 MEELQDDYED 20 MMEENLEQEE 30 YEDPDIPESQ 40 MEEPAAHDTE 50 ATATDYHTTS 60 HPGTHKVYVE 70 LQELVMDEKN 80 QELRWMEAAR 90 WVQLEENLGE 100 NGAWGRPHLS 110 HLTFWSLLEL 120 RRVFTKGTVL 130 LDLQETSLAG 140 VANQLLDRFI 150 FEDQIRPQDR 160 EELLRALLLK 170 HSHAGELEAL 180 GGVKPAVLTR 190 SGDPSQPLLP 200 QHSSLETQLF 210 CEQGDGGTEG 220 HSPSGILEKI 230 PPDSEATLVL 240 VGRADFLEQP 250 VLGFVRLQEA 260 AELEAVELPV 270 PIRFLFVLLG 280 PEAPHIDYTQ 290 LGRAAATLMS 300 ERVFRIDAYM 310 AQSRGELLHS 320 LEGFLDCSLV 330 LPPTDAPSEQ 340 ALLSLVPVQR 350 ELLRRRYQSS 360 PAKPDSSFYK 370 GLDLNGGPDD 380 PLQQTGQLFG 390 GLVRDIRRRY 400 PYYLSDITDA 410 FSPQVLAAVI 420 FIYFAALSPA 430 ITFGGLLGEK 440 TRNQMGVSEL 450 LISTAVQGIL 460 FALLGAQPLL 470 VVGFSGPLLV 480 FEEAFFSFCE 490 TNGLEYIVGR 500 VWIGFWLILL 510 VVLVVAFEGS 520 FLVRFISRYT 530 QEIFSFLISL 540 IFIYETFSKL 550 IKIFQDHPLQ 560 KTYNYNVLMV 570 PKPQGPLPNT 580 ALLSLVLMAG 590 TFFFAMMLRK 600 FKNSSYFPGK 610 LRRVIGDFGV 620 PISILIMVLV 630 DFFIQDTYTQ 640 KLSVPDGFKV 650 SNSSARGWVI 660 HPLGLRSEFP 670 IWMMFASALP 680 ALLVFILIFL 690 ESQITTLIVS 700 KPERKMVKGS 710 GFHLDLLLVV 720 GMGGVAALFG 730 MPWLSATTVR 740 SVTHANALTV 750 MGKASTPGAA 760 AQIQEVKEQR 770 ISGLLVAVLV 780 GLSILMEPIL 790 SRIPLAVLFG 800 IFLYMGVTSL 810 SGIQLFDRIL 820 LLFKPPKYHP 830 DVPYVKRVKT 840 WRMHLFTGIQ 850 IICLAVLWVV 860 KSTPASLALP 870 FVLILTVPLR 880 RVLLPLIFRN 890 VELQCLDADD 900 AKATFDEEEG 910 RDEYDEVAMP V

Gene Ontology

Classification GO ID Description
Cellular Component GO:0170014 ankyrin-1 complex
Cellular Component GO:0016323 basolateral plasma membrane
Cellular Component GO:0072562 blood microparticle
Cellular Component GO:0030863 cortical cytoskeleton
Cellular Component GO:0009898 cytoplasmic side of plasma membrane
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0030018 Z disc
Molecular Function GO:0030506 ankyrin binding
Molecular Function GO:0015106 bicarbonate transmembrane transporter activity
Molecular Function GO:0015108 chloride transmembrane transporter activity
Molecular Function GO:0140900 chloride:bicarbonate antiporter activity
Molecular Function GO:0030492 hemoglobin binding
Molecular Function GO:0008509 monoatomic anion transmembrane transporter activity
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0043495 protein-membrane adaptor activity
Molecular Function GO:0005452 solute:inorganic anion antiporter activity
Biological Process GO:0015701 bicarbonate transport
Biological Process GO:1902476 chloride transmembrane transport
Biological Process GO:0006821 chloride transport
Biological Process GO:0006873 intracellular monoatomic ion homeostasis
Biological Process GO:0006820 monoatomic anion transport
Biological Process GO:0051453 regulation of intracellular pH
Biological Process GO:0055085 transmembrane transport

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.