Search Results
Overview
| Uniprot ID | P02741 |
|---|---|
| Protein Name | C-reactive protein |
| Gene Name | CRP |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 31 | RKAFVFPKESDTSYV |
Function
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells
Protein Sequence
10
MEKLLCFLVL
20
TSLSHAFGQT
30
DMSRKAFVFP
40
KESDTSYVSL
50
KAPLTKPLKA
60
FTVCLHFYTE
70
LSSTRGYSIF
80
SYATKRQDNE
90
ILIFWSKDIG
100
YSFTVGGSEI
110
LFEVPEVTVA
120
PVHICTSWES
130
ASGIVEFWVD
140
GKPRVRKSLK
150
KGYTVGAEAS
160
IILGQEQDSF
170
GGNFEGSQSL
180
VGDIGNVNMW
190
DFVLSPDEIN
200
TIYLGGPFSP
210
NVLNWRALKY
220
EVQGEVFTKP
QLWP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0033265 | choline binding |
| Molecular Function | GO:0001849 | complement component C1q complex binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0030169 | low-density lipoprotein particle binding |
| Molecular Function | GO:0050750 | low-density lipoprotein particle receptor binding |
| Biological Process | GO:0006953 | acute-phase response |
| Biological Process | GO:0050830 | defense response to Gram-positive bacterium |
| Biological Process | GO:0006954 | inflammatory response |
| Biological Process | GO:0045087 | innate immune response |
| Biological Process | GO:0010888 | negative regulation of lipid storage |
| Biological Process | GO:0010745 | negative regulation of macrophage derived foam cell differentiation |
| Biological Process | GO:0032945 | negative regulation of mononuclear cell proliferation |
| Biological Process | GO:0008228 | opsonization |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0032930 | positive regulation of superoxide anion generation |
| Biological Process | GO:0032677 | regulation of interleukin-8 production |
| Biological Process | GO:0042310 | vasoconstriction |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.