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Overview

Uniprot IDP02743
Protein NameSerum amyloid P-component
Gene NameAPCS
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
102 GRHKVTSKVIEKFPA
162 EQDSYGGKFDRSQSF
84 DNELLVYKERVGEYS

Function

Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin

Protein Sequence

10 MNKPLLWISV 20 LTSLLEAFAH 30 TDLSGKVFVF 40 PRESVTDHVN 50 LITPLEKPLQ 60 NFTLCFRAYS 70 DLSRAYSLFS 80 YNTQGRDNEL 90 LVYKERVGEY 100 SLYIGRHKVT 110 SKVIEKFPAP 120 VHICVSWESS 130 SGIAEFWING 140 TPLVKKGLRQ 150 GYFVEAQPKI 160 VLGQEQDSYG 170 GKFDRSQSFV 180 GEIGDLYMWD 190 SVLPPENILS 200 AYQGTPLPAN 210 ILDWQALNYE 220 IRGYVIIKPL VWV

Gene Ontology

Classification GO ID Description
Molecular Function GO:0046790 virion binding
Biological Process GO:0006953 acute-phase response
Biological Process GO:0051131 chaperone-mediated protein complex assembly
Biological Process GO:0046597 host-mediated suppression of symbiont invasion
Biological Process GO:0045087 innate immune response
Biological Process GO:0044871 negative regulation by host of viral glycoprotein metabolic process
Biological Process GO:0002674 negative regulation of acute inflammatory response
Biological Process GO:1903019 negative regulation of glycoprotein metabolic process
Biological Process GO:0045656 negative regulation of monocyte differentiation
Biological Process GO:0048525 negative regulation of viral process
Biological Process GO:0061045 negative regulation of wound healing
Biological Process GO:0006457 protein folding
Cellular Component GO:0072562 blood microparticle
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0030246 carbohydrate binding
Molecular Function GO:0001849 complement component C1q complex binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0051082 unfolded protein binding

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[3] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.