Overview
| Uniprot ID | P02748 |
|---|
| Protein Name | Complement component C9 |
|---|
| Gene Name | C9 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 483 |
IYNLVPVKMKNAHLK |
Function
Pore-forming component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis (PubMed:22832194, PubMed:26841837, PubMed:26841934, PubMed:27052168, PubMed:30552328, PubMed:6177822, PubMed:9212048, PubMed:9634479). The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways (PubMed:39914456, PubMed:39814882, PubMed:9212048, PubMed:9634479). The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:9212048, PubMed:9634479). Constitutes the pore-forming subunit of the MAC complex: during MAC assembly, C9 associates with the C5b8 intermediate complex, and polymerizes to complete the pore (PubMed:26841934, PubMed:30111885, PubMed:30552328, PubMed:34752492, PubMed:4055801, PubMed:6177822)
Protein Sequence
10
MSACRSFAVA
20
ICILEISILT
30
AQYTTSYDPE
40
LTESSGSASH
50
IDCRMSPWSE
60
WSQCDPCLRQ
70
MFRSRSIEVF
80
GQFNGKRCTD
90
AVGDRRQCVP
100
TEPCEDAEDD
110
CGNDFQCSTG
120
RCIKMRLRCN
130
GDNDCGDFSD
140
EDDCESEPRP
150
PCRDRVVEES
160
ELARTAGYGI
170
NILGMDPLST
180
PFDNEFYNGL
190
CNRDRDGNTL
200
TYYRRPWNVA
210
SLIYETKGEK
220
NFRTEHYEEQ
230
IEAFKSIIQE
240
KTSNFNAAIS
250
LKFTPTETNK
260
AEQCCEETAS
270
SISLHGKGSF
280
RFSYSKNETY
290
QLFLSYSSKK
300
EKMFLHVKGE
310
IHLGRFVMRN
320
RDVVLTTTFV
330
DDIKALPTTY
340
EKGEYFAFLE
350
TYGTHYSSSG
360
SLGGLYELIY
370
VLDKASMKRK
380
GVELKDIKRC
390
LGYHLDVSLA
400
FSEISVGAEF
410
NKDDCVKRGE
420
GRAVNITSEN
430
LIDDVVSLIR
440
GGTRKYAFEL
450
KEKLLRGTVI
460
DVTDFVNWAS
470
SINDAPVLIS
480
QKLSPIYNLV
490
PVKMKNAHLK
500
KQNLERAIED
510
YINEFSVRKC
520
HTCQNGGTVI
530
LMDGKCLCAC
540
PFKFEGIACE
550
ISKQKISEGL
PALEFPNEK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0072562 |
blood microparticle |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005576 |
extracellular region |
| Cellular Component |
GO:0005615 |
extracellular space |
| Cellular Component |
GO:0005579 |
membrane attack complex |
| Cellular Component |
GO:0044218 |
other organism cell membrane |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Biological Process |
GO:0001906 |
cell killing |
| Biological Process |
GO:0006956 |
complement activation |
| Biological Process |
GO:0006957 |
complement activation, alternative pathway |
| Biological Process |
GO:0006958 |
complement activation, classical pathway |
| Biological Process |
GO:0160257 |
complement activation, GZMK pathway |
| Biological Process |
GO:0031640 |
killing of cells of another organism |
| Biological Process |
GO:0050778 |
positive regulation of immune response |
| Biological Process |
GO:0051260 |
protein homooligomerization |
| Biological Process |
GO:0055085 |
transmembrane transport |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.