Search Results
Overview
| Uniprot ID | P02749 |
|---|---|
| Protein Name | Beta-2-glycoprotein 1 |
| Gene Name | APOH |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 270 | SCKVPVKKATVVYQG |
| 287 | VKIQEKFKNGMLHGD |
| 301 | DKVSFFCKNKEKKCS |
| 306 | FCKNKEKKCSYTEDA |
| 336 | HSSLAFWKTDASDVK |
| 52 | EEITYSCKPGYVSRG |
| 63 | VSRGGMRKFICPLTG |
Function
Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells
Protein Sequence
10
MISPVLILFS
20
SFLCHVAIAG
30
RTCPKPDDLP
40
FSTVVPLKTF
50
YEPGEEITYS
60
CKPGYVSRGG
70
MRKFICPLTG
80
LWPINTLKCT
90
PRVCPFAGIL
100
ENGAVRYTTF
110
EYPNTISFSC
120
NTGFYLNGAD
130
SAKCTEEGKW
140
SPELPVCAPI
150
ICPPPSIPTF
160
ATLRVYKPSA
170
GNNSLYRDTA
180
VFECLPQHAM
190
FGNDTITCTT
200
HGNWTKLPEC
210
REVKCPFPSR
220
PDNGFVNYPA
230
KPTLYYKDKA
240
TFGCHDGYSL
250
DGPEEIECTK
260
LGNWSAMPSC
270
KASCKVPVKK
280
ATVVYQGERV
290
KIQEKFKNGM
300
LHGDKVSFFC
310
KNKEKKCSYT
320
EDAQCIDGTI
330
EVPKCFKEHS
340
SLAFWKTDAS
DVKPC
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0042627 | chylomicron |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0034364 | high-density lipoprotein particle |
| Cellular Component | GO:0031089 | platelet dense granule lumen |
| Cellular Component | GO:0034361 | very-low-density lipoprotein particle |
| Molecular Function | GO:0008201 | heparin binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0035473 | lipase binding |
| Molecular Function | GO:0008289 | lipid binding |
| Molecular Function | GO:0060230 | lipoprotein lipase activator activity |
| Molecular Function | GO:0005543 | phospholipid binding |
| Biological Process | GO:0007597 | blood coagulation, intrinsic pathway |
| Biological Process | GO:0034371 | chylomicron remodeling |
| Biological Process | GO:0016525 | negative regulation of angiogenesis |
| Biological Process | GO:0030195 | negative regulation of blood coagulation |
| Biological Process | GO:0010596 | negative regulation of endothelial cell migration |
| Biological Process | GO:0001937 | negative regulation of endothelial cell proliferation |
| Biological Process | GO:0051918 | negative regulation of fibrinolysis |
| Biological Process | GO:0033033 | negative regulation of myeloid cell apoptotic process |
| Biological Process | GO:0034392 | negative regulation of smooth muscle cell apoptotic process |
| Biological Process | GO:0031639 | plasminogen activation |
| Biological Process | GO:0030194 | positive regulation of blood coagulation |
| Biological Process | GO:0090208 | positive regulation of triglyceride metabolic process |
| Biological Process | GO:0051917 | regulation of fibrinolysis |
| Biological Process | GO:0034197 | triglyceride transport |
| Biological Process | GO:0034372 | very-low-density lipoprotein particle remodeling |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.