Search Results

Overview

Uniprot IDP02751
Protein NameFibronectin
Gene NameFN1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
100 AEETCFDKYTGNTYR
1050 NVGPSVSKYPLRNLQ
1070 TVSLVAIKGNQESPK
1623 GDSPASSKPISINYR
1670 YRVTTTPKNGPGPTK
1677 KNGPGPTKTKTAGPD
180 GKGEWTCKPIAEKCF
2027 RITGYIIKYEKPGSP
2030 GYIIKYEKPGSPPRE
2072 IALKNNQKSEPLIGR
57 PGCYDNGKHYQINQQ
987 VSHGRESKPLTAQQT

Function

Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin (PubMed:3024962, PubMed:3593230, PubMed:3900070, PubMed:7989369). Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape (PubMed:3024962, PubMed:3593230, PubMed:3900070, PubMed:7989369). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). Acts as a ligand for the LILRB4 receptor, inhibiting FCGR1A/CD64-mediated monocyte activation (PubMed:34089617)

Protein Sequence

10 MLRGPGPGLL 20 LLAVQCLGTA 30 VPSTGASKSK 40 RQAQQMVQPQ 50 SPVAVSQSKP 60 GCYDNGKHYQ 70 INQQWERTYL 80 GNALVCTCYG 90 GSRGFNCESK 100 PEAEETCFDK 110 YTGNTYRVGD 120 TYERPKDSMI 130 WDCTCIGAGR 140 GRISCTIANR 150 CHEGGQSYKI 160 GDTWRRPHET 170 GGYMLECVCL 180 GNGKGEWTCK 190 PIAEKCFDHA 200 AGTSYVVGET 210 WEKPYQGWMM 220 VDCTCLGEGS 230 GRITCTSRNR 240 CNDQDTRTSY 250 RIGDTWSKKD 260 NRGNLLQCIC 270 TGNGRGEWKC 280 ERHTSVQTTS 290 SGSGPFTDVR 300 AAVYQPQPHP 310 QPPPYGHCVT 320 DSGVVYSVGM 330 QWLKTQGNKQ 340 MLCTCLGNGV 350 SCQETAVTQT 360 YGGNSNGEPC 370 VLPFTYNGRT 380 FYSCTTEGRQ 390 DGHLWCSTTS 400 NYEQDQKYSF 410 CTDHTVLVQT 420 RGGNSNGALC 430 HFPFLYNNHN 440 YTDCTSEGRR 450 DNMKWCGTTQ 460 NYDADQKFGF 470 CPMAAHEEIC 480 TTNEGVMYRI 490 GDQWDKQHDM 500 GHMMRCTCVG 510 NGRGEWTCIA 520 YSQLRDQCIV 530 DDITYNVNDT 540 FHKRHEEGHM 550 LNCTCFGQGR 560 GRWKCDPVDQ 570 CQDSETGTFY 580 QIGDSWEKYV 590 HGVRYQCYCY 600 GRGIGEWHCQ 610 PLQTYPSSSG 620 PVEVFITETP 630 SQPNSHPIQW 640 NAPQPSHISK 650 YILRWRPKNS 660 VGRWKEATIP 670 GHLNSYTIKG 680 LKPGVVYEGQ 690 LISIQQYGHQ 700 EVTRFDFTTT 710 STSTPVTSNT 720 VTGETTPFSP 730 LVATSESVTE 740 ITASSFVVSW 750 VSASDTVSGF 760 RVEYELSEEG 770 DEPQYLDLPS 780 TATSVNIPDL 790 LPGRKYIVNV 800 YQISEDGEQS 810 LILSTSQTTA 820 PDAPPDTTVD 830 QVDDTSIVVR 840 WSRPQAPITG 850 YRIVYSPSVE 860 GSSTELNLPE 870 TANSVTLSDL 880 QPGVQYNITI 890 YAVEENQEST 900 PVVIQQETTG 910 TPRSDTVPSP 920 RDLQFVEVTD 930 VKVTIMWTPP 940 ESAVTGYRVD 950 VIPVNLPGEH 960 GQRLPISRNT 970 FAEVTGLSPG 980 VTYYFKVFAV 990 SHGRESKPLT 1000 AQQTTKLDAP 1010 TNLQFVNETD 1020 STVLVRWTPP 1030 RAQITGYRLT 1040 VGLTRRGQPR 1050 QYNVGPSVSK 1060 YPLRNLQPAS 1070 EYTVSLVAIK 1080 GNQESPKATG 1090 VFTTLQPGSS 1100 IPPYNTEVTE 1110 TTIVITWTPA 1120 PRIGFKLGVR 1130 PSQGGEAPRE 1140 VTSDSGSIVV 1150 SGLTPGVEYV 1160 YTIQVLRDGQ 1170 ERDAPIVNKV 1180 VTPLSPPTNL 1190 HLEANPDTGV 1200 LTVSWERSTT 1210 PDITGYRITT 1220 TPTNGQQGNS 1230 LEEVVHADQS 1240 SCTFDNLSPG 1250 LEYNVSVYTV 1260 KDDKESVPIS 1270 DTIIPEVPQL 1280 TDLSFVDITD 1290 SSIGLRWTPL 1300 NSSTIIGYRI 1310 TVVAAGEGIP 1320 IFEDFVDSSV 1330 GYYTVTGLEP 1340 GIDYDISVIT 1350 LINGGESAPT 1360 TLTQQTAVPP 1370 PTDLRFTNIG 1380 PDTMRVTWAP 1390 PPSIDLTNFL 1400 VRYSPVKNEE 1410 DVAELSISPS 1420 DNAVVLTNLL 1430 PGTEYVVSVS 1440 SVYEQHESTP 1450 LRGRQKTGLD 1460 SPTGIDFSDI 1470 TANSFTVHWI 1480 APRATITGYR 1490 IRHHPEHFSG 1500 RPREDRVPHS 1510 RNSITLTNLT 1520 PGTEYVVSIV 1530 ALNGREESPL 1540 LIGQQSTVSD 1550 VPRDLEVVAA 1560 TPTSLLISWD 1570 APAVTVRYYR 1580 ITYGETGGNS 1590 PVQEFTVPGS 1600 KSTATISGLK 1610 PGVDYTITVY 1620 AVTGRGDSPA 1630 SSKPISINYR 1640 TEIDKPSQMQ 1650 VTDVQDNSIS 1660 VKWLPSSSPV 1670 TGYRVTTTPK 1680 NGPGPTKTKT 1690 AGPDQTEMTI 1700 EGLQPTVEYV 1710 VSVYAQNPSG 1720 ESQPLVQTAV 1730 TNIDRPKGLA 1740 FTDVDVDSIK 1750 IAWESPQGQV 1760 SRYRVTYSSP 1770 EDGIHELFPA 1780 PDGEEDTAEL 1790 QGLRPGSEYT 1800 VSVVALHDDM 1810 ESQPLIGTQS 1820 TAIPAPTDLK 1830 FTQVTPTSLS 1840 AQWTPPNVQL 1850 TGYRVRVTPK 1860 EKTGPMKEIN 1870 LAPDSSSVVV 1880 SGLMVATKYE 1890 VSVYALKDTL 1900 TSRPAQGVVT 1910 TLENVSPPRR 1920 ARVTDATETT 1930 ITISWRTKTE 1940 TITGFQVDAV 1950 PANGQTPIQR 1960 TIKPDVRSYT 1970 ITGLQPGTDY 1980 KIYLYTLNDN 1990 ARSSPVVIDA 2000 STAIDAPSNL 2010 RFLATTPNSL 2020 LVSWQPPRAR 2030 ITGYIIKYEK 2040 PGSPPREVVP 2050 RPRPGVTEAT 2060 ITGLEPGTEY 2070 TIYVIALKNN 2080 QKSEPLIGRK 2090 KTDELPQLVT 2100 LPHPNLHGPE 2110 ILDVPSTVQK 2120 TPFVTHPGYD 2130 TGNGIQLPGT 2140 SGQQPSVGQQ 2150 MIFEEHGFRR 2160 TTPPTTATPI 2170 RHRPRPYPPN 2180 VGEEIQIGHI 2190 PREDVDYHLY 2200 PHGPGLNPNA 2210 STGQEALSQT 2220 TISWAPFQDT 2230 SEYIISCHPV 2240 GTDEEPLQFR 2250 VPGTSTSATL 2260 TGLTRGATYN 2270 VIVEALKDQQ 2280 RHKVREEVVT 2290 VGNSVNEGLN 2300 QPTDDSCFDP 2310 YTVSHYAVGD 2320 EWERMSESGF 2330 KLLCQCLGFG 2340 SGHFRCDSSR 2350 WCHDNGVNYK 2360 IGEKWDRQGE 2370 NGQMMSCTCL 2380 GNGKGEFKCD 2390 PHEATCYDDG 2400 KTYHVGEQWQ 2410 KEYLGAICSC 2420 TCFGGQRGWR 2430 CDNCRRPGGE 2440 PSPEGTTGQS 2450 YNQYSQRYHQ 2460 RTNTNVNCPI 2470 ECFMPLDVQA DREDSRE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016324 apical plasma membrane
Cellular Component GO:0005604 basement membrane
Cellular Component GO:0072562 blood microparticle
Cellular Component GO:0005788 endoplasmic reticulum lumen
Cellular Component GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005577 fibrinogen complex
Cellular Component GO:0061800 fibronectin fibril
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0031093 platelet alpha granule lumen
Molecular Function GO:0005518 collagen binding
Molecular Function GO:0005201 extracellular matrix structural constituent
Molecular Function GO:0008201 heparin binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0005178 integrin binding
Molecular Function GO:0016504 peptidase activator activity
Molecular Function GO:0002020 protease binding
Molecular Function GO:0043394 proteoglycan binding
Molecular Function GO:0048018 receptor ligand activity
Molecular Function GO:0005102 signaling receptor binding
Biological Process GO:0006953 acute-phase response
Biological Process GO:0001525 angiogenesis
Biological Process GO:0051702 biological process involved in interaction with symbiont
Biological Process GO:0072378 blood coagulation, fibrin clot formation
Biological Process GO:0007155 cell adhesion
Biological Process GO:0007160 cell-matrix adhesion
Biological Process GO:0007044 cell-substrate junction assembly
Biological Process GO:0035987 endodermal cell differentiation
Biological Process GO:0043542 endothelial cell migration
Biological Process GO:0048484 enteric nervous system development
Biological Process GO:0007507 heart development
Biological Process GO:0033622 integrin activation
Biological Process GO:0007229 integrin-mediated signaling pathway
Biological Process GO:0150102 negative regulation of monocyte activation
Biological Process GO:0071635 negative regulation of transforming growth factor beta production
Biological Process GO:0007399 nervous system development
Biological Process GO:0001755 neural crest cell migration
Biological Process GO:1901166 neural crest cell migration involved in autonomic nervous system development
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0048146 positive regulation of fibroblast proliferation
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Process GO:1904237 positive regulation of substrate-dependent cell migration, cell attachment to substrate
Biological Process GO:0008360 regulation of cell shape
Biological Process GO:0070372 regulation of ERK1 and ERK2 cascade
Biological Process GO:0001932 regulation of protein phosphorylation
Biological Process GO:0014850 response to muscle activity
Biological Process GO:0009611 response to wounding
Biological Process GO:0034446 substrate adhesion-dependent cell spreading

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.