Search Results
Overview
| Uniprot ID | P02753 |
|---|---|
| Protein Name | Retinol-binding protein 4 |
| Gene Name | RBP4 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 107 | DPAKFKMKYWGVASF |
| 168 | GLPPEAQKIVRQRQE |
| 35 | RVKENFDKARFSGTW |
Function
Retinol-binding protein that mediates retinol transport in blood plasma (PubMed:5541771). Delivers retinol from the liver stores to the peripheral tissues (Probable). Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane (PubMed:22665496)
Protein Sequence
10
MKWVWALLLL
20
AALGSGRAER
30
DCRVSSFRVK
40
ENFDKARFSG
50
TWYAMAKKDP
60
EGLFLQDNIV
70
AEFSVDETGQ
80
MSATAKGRVR
90
LLNNWDVCAD
100
MVGTFTDTED
110
PAKFKMKYWG
120
VASFLQKGND
130
DHWIVDTDYD
140
TYAVQYSCRL
150
LNLDGTCADS
160
YSFVFSRDPN
170
GLPPEAQKIV
180
RQRQEELCLA
190
RQYRLIVHNG
200
YCDGRSERNL
L
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0060044 | negative regulation of cardiac muscle cell proliferation |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:1904768 | all-trans-retinol binding |
| Molecular Function | GO:0140104 | molecular carrier activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0016918 | retinal binding |
| Molecular Function | GO:0019841 | retinol binding |
| Molecular Function | GO:0034632 | retinol transmembrane transporter activity |
| Biological Process | GO:0048738 | cardiac muscle tissue development |
| Biological Process | GO:0048562 | embryonic organ morphogenesis |
| Biological Process | GO:0060059 | embryonic retina morphogenesis in camera-type eye |
| Biological Process | GO:0048706 | embryonic skeletal system development |
| Biological Process | GO:0001654 | eye development |
| Biological Process | GO:0048807 | female genitalia morphogenesis |
| Biological Process | GO:0006094 | gluconeogenesis |
| Biological Process | GO:0042593 | glucose homeostasis |
| Biological Process | GO:0007507 | heart development |
| Biological Process | GO:0060347 | heart trabecula formation |
| Biological Process | GO:0030324 | lung development |
| Biological Process | GO:0030277 | maintenance of gastrointestinal epithelium |
| Biological Process | GO:0002639 | positive regulation of immunoglobulin production |
| Biological Process | GO:0032024 | positive regulation of insulin secretion |
| Biological Process | GO:0045471 | response to ethanol |
| Biological Process | GO:0014850 | response to muscle activity |
| Biological Process | GO:0032526 | response to retinoic acid |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0001523 | retinoid metabolic process |
| Biological Process | GO:0042572 | retinol metabolic process |
| Biological Process | GO:0034633 | retinol transport |
| Biological Process | GO:0060157 | urinary bladder development |
| Biological Process | GO:0060065 | uterus development |
| Biological Process | GO:0060068 | vagina development |
| Biological Process | GO:0007601 | visual perception |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.