Search Results
Overview
| Uniprot ID | P02763 |
|---|---|
| Protein Name | Alpha-1-acid glycoprotein 1 |
| Gene Name | ORM1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 170 | LDCLRIPKSDVVYTD |
| 179 | DVVYTDWKKDKCEPL |
| 182 | YTDWKKDKCEPLEKQ |
Function
Functions as a transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction
Protein Sequence
10
MALSWVLTVL
20
SLLPLLEAQI
30
PLCANLVPVP
40
ITNATLDRIT
50
GKWFYIASAF
60
RNEEYNKSVQ
70
EIQATFFYFT
80
PNKTEDTIFL
90
REYQTRQDQC
100
IYNTTYLNVQ
110
RENGTISRYV
120
GGQEHFAHLL
130
ILRDTKTYML
140
AFDVNDEKNW
150
GLSVYADKPE
160
TTKEQLGEFY
170
EALDCLRIPK
180
SDVVYTDWKK
190
DKCEPLEKQH
200
EKERKQEEGE
S
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0072562 | blood microparticle |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0031093 | platelet alpha granule lumen |
| Cellular Component | GO:0035580 | specific granule lumen |
| Cellular Component | GO:1904724 | tertiary granule lumen |
| Biological Process | GO:0006953 | acute-phase response |
| Biological Process | GO:0006954 | inflammatory response |
| Biological Process | GO:0032715 | negative regulation of interleukin-6 production |
| Biological Process | GO:0032720 | negative regulation of tumor necrosis factor production |
| Biological Process | GO:0032731 | positive regulation of interleukin-1 beta production |
| Biological Process | GO:0032732 | positive regulation of interleukin-1 production |
| Biological Process | GO:0032760 | positive regulation of tumor necrosis factor production |
| Biological Process | GO:0002682 | regulation of immune system process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.