Search Results
Overview
| Uniprot ID | P02765 |
|---|---|
| Protein Name | Alpha-2-HS-glycoprotein |
| Gene Name | AHSG |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 106 | RCSVRQLKEHAVEGD |
| 120 | DCDFQLLKLDGKFSV |
| 124 | QLLKLDGKFSVVYAK |
| 211 | SGTDCVAKEATEAAK |
| 218 | KEATEAAKCNLLAEK |
Function
Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions
Protein Sequence
10
MKSLVLLLCL
20
AQLWGCHSAP
30
HGPGLIYRQP
40
NCDDPETEEA
50
ALVAIDYINQ
60
NLPWGYKHTL
70
NQIDEVKVWP
80
QQPSGELFEI
90
EIDTLETTCH
100
VLDPTPVARC
110
SVRQLKEHAV
120
EGDCDFQLLK
130
LDGKFSVVYA
140
KCDSSPDSAE
150
DVRKVCQDCP
160
LLAPLNDTRV
170
VHAAKAALAA
180
FNAQNNGSNF
190
QLEEISRAQL
200
VPLPPSTYVE
210
FTVSGTDCVA
220
KEATEAAKCN
230
LLAEKQYGFC
240
KATLSEKLGG
250
AEVAVTCMVF
260
QTQPVSSQPQ
270
PEGANEAVPT
280
PVVDPDAPPS
290
PPLGAPGLPP
300
AGSPPDSHVL
310
LAAPPGHQLH
320
RAHYDLRHTF
330
MGVVSLGSPS
340
GEVSHPRKTR
350
TVVQPSVGAA
360
AGPVVPPCPG
RIRHFKV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0072562 | blood microparticle |
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0031093 | platelet alpha granule lumen |
| Cellular Component | GO:0034774 | secretory granule lumen |
| Molecular Function | GO:0004869 | cysteine-type endopeptidase inhibitor activity |
| Molecular Function | GO:0004866 | endopeptidase inhibitor activity |
| Molecular Function | GO:0019210 | kinase inhibitor activity |
| Biological Process | GO:0006953 | acute-phase response |
| Biological Process | GO:0030502 | negative regulation of bone mineralization |
| Biological Process | GO:0046627 | negative regulation of insulin receptor signaling pathway |
| Biological Process | GO:0006907 | pinocytosis |
| Biological Process | GO:0050766 | positive regulation of phagocytosis |
| Biological Process | GO:0030500 | regulation of bone mineralization |
| Biological Process | GO:0050727 | regulation of inflammatory response |
| Biological Process | GO:0001501 | skeletal system development |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.