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Overview

Uniprot IDP02770
Protein NameAlbumin
Gene NameAlb
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
103 DKLCAIPKLRDNYGE
205 KAACLTPKLDAVKEK
212 KLDAVKEKALVAAVR
223 AAVRQRMKCSSMQRF
267 TDVTKINKECCHGDL
28 VFRREAHKSEIAHRF
305 KLQACCDKPVLQKSQ
36 SEIAHRFKDLGEQHF
376 LLLRLAKKYEATLEK
413 EEPKNLVKTNCELYE
460 NLGRVGTKCCTLPEA
496 EKTPVSEKVTKCCSG
499 PVSEKVTKCCSGSLV
549 DKEKQIKKQTALAEL
558 TALAELVKHKPKATE

Function

Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (By similarity). Does not prevent iron uptake by the bacterial siderophore aerobactin (By similarity)

Protein Sequence

10 MKWVTFLLLL 20 FISGSAFSRG 30 VFRREAHKSE 40 IAHRFKDLGE 50 QHFKGLVLIA 60 FSQYLQKCPY 70 EEHIKLVQEV 80 TDFAKTCVAD 90 ENAENCDKSI 100 HTLFGDKLCA 110 IPKLRDNYGE 120 LADCCAKQEP 130 ERNECFLQHK 140 DDNPNLPPFQ 150 RPEAEAMCTS 160 FQENPTSFLG 170 HYLHEVARRH 180 PYFYAPELLY 190 YAEKYNEVLT 200 QCCTESDKAA 210 CLTPKLDAVK 220 EKALVAAVRQ 230 RMKCSSMQRF 240 GERAFKAWAV 250 ARMSQRFPNA 260 EFAEITKLAT 270 DVTKINKECC 280 HGDLLECADD 290 RAELAKYMCE 300 NQATISSKLQ 310 ACCDKPVLQK 320 SQCLAEIEHD 330 NIPADLPSIA 340 ADFVEDKEVC 350 KNYAEAKDVF 360 LGTFLYEYSR 370 RHPDYSVSLL 380 LRLAKKYEAT 390 LEKCCAEGDP 400 PACYGTVLAE 410 FQPLVEEPKN 420 LVKTNCELYE 430 KLGEYGFQNA 440 VLVRYTQKAP 450 QVSTPTLVEA 460 ARNLGRVGTK 470 CCTLPEAQRL 480 PCVEDYLSAI 490 LNRLCVLHEK 500 TPVSEKVTKC 510 CSGSLVERRP 520 CFSALTVDET 530 YVPKEFKAET 540 FTFHSDICTL 550 PDKEKQIKKQ 560 TALAELVKHK 570 PKATEDQLKT 580 VMGDFAQFVD 590 KCCKAADKDN 600 CFATEGPNLV ARSKEALA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005604 basement membrane
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0003677 DNA binding
Molecular Function GO:1903981 enterobactin binding
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0140272 exogenous protein binding
Molecular Function GO:0005504 fatty acid binding
Molecular Function GO:0020037 heme binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0072341 modified amino acid binding
Molecular Function GO:0140104 molecular carrier activity
Molecular Function GO:0051087 protein-folding chaperone binding
Molecular Function GO:0030170 pyridoxal phosphate binding
Molecular Function GO:0036094 small molecule binding
Molecular Function GO:0015643 toxic substance binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0015723 bilirubin transport
Biological Process GO:0072732 cellular response to calcium ion starvation
Biological Process GO:0009267 cellular response to starvation
Biological Process GO:0051902 negative regulation of mitochondrial depolarization
Biological Process GO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep
Biological Process GO:1904614 response to biphenyl
Biological Process GO:0046689 response to mercury ion
Biological Process GO:0007584 response to nutrient
Biological Process GO:0031667 response to nutrient levels
Biological Process GO:0070541 response to platinum ion
Biological Process GO:0042311 vasodilation

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.