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Overview

Uniprot IDP02771
Protein NameAlpha-fetoprotein
Gene NameAFP
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
242 FQAITVTKLSQKFTK

Function

Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties

Protein Sequence

10 MKWVESIFLI 20 FLLNFTESRT 30 LHRNEYGIAS 40 ILDSYQCTAE 50 ISLADLATIF 60 FAQFVQEATY 70 KEVSKMVKDA 80 LTAIEKPTGD 90 EQSSGCLENQ 100 LPAFLEELCH 110 EKEILEKYGH 120 SDCCSQSEEG 130 RHNCFLAHKK 140 PTPASIPLFQ 150 VPEPVTSCEA 160 YEEDRETFMN 170 KFIYEIARRH 180 PFLYAPTILL 190 WAARYDKIIP 200 SCCKAENAVE 210 CFQTKAATVT 220 KELRESSLLN 230 QHACAVMKNF 240 GTRTFQAITV 250 TKLSQKFTKV 260 NFTEIQKLVL 270 DVAHVHEHCC 280 RGDVLDCLQD 290 GEKIMSYICS 300 QQDTLSNKIT 310 ECCKLTTLER 320 GQCIIHAEND 330 EKPEGLSPNL 340 NRFLGDRDFN 350 QFSSGEKNIF 360 LASFVHEYSR 370 RHPQLAVSVI 380 LRVAKGYQEL 390 LEKCFQTENP 400 LECQDKGEEE 410 LQKYIQESQA 420 LAKRSCGLFQ 430 KLGEYYLQNA 440 FLVAYTKKAP 450 QLTSSELMAI 460 TRKMAATAAT 470 CCQLSEDKLL 480 ACGEGAADII 490 IGHLCIRHEM 500 TPVNPGVGQC 510 CTSSYANRRP 520 CFSSLVVDET 530 YVPPAFSDDK 540 FIFHKDLCQA 550 QGVALQTMKQ 560 EFLINLVKQK 570 PQITEEQLEA 580 VIADFSGLLE 590 KCCQGQEQEV 600 CFAEEGQKLI SKTRAALGV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005788 endoplasmic reticulum lumen
Cellular Component GO:0005615 extracellular space
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0036094 small molecule binding
Biological Process GO:0031667 response to nutrient levels

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.