Search Results
Overview
| Uniprot ID | P02774 |
|---|---|
| Protein Name | Vitamin D-binding protein |
| Gene Name | GC |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 207 | LKERLQLKHLSLLTT |
| 229 | QYAAYGEKKSRLSNL |
| 30 | YEKNKVCKEFSHLGK |
| 341 | VCDPGNTKVMDKYTF |
| 394 | AKGPLLKKELSSFID |
| 429 | LAERLKAKLPDATPT |
| 51 | SLVLYSRKFPSGTFE |
Function
Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation
Protein Sequence
10
MKRVLVLLLA
20
VAFGHALERG
30
RDYEKNKVCK
40
EFSHLGKEDF
50
TSLSLVLYSR
60
KFPSGTFEQV
70
SQLVKEVVSL
80
TEACCAEGAD
90
PDCYDTRTSA
100
LSAKSCESNS
110
PFPVHPGTAE
120
CCTKEGLERK
130
LCMAALKHQP
140
QEFPTYVEPT
150
NDEICEAFRK
160
DPKEYANQFM
170
WEYSTNYGQA
180
PLSLLVSYTK
190
SYLSMVGSCC
200
TSASPTVCFL
210
KERLQLKHLS
220
LLTTLSNRVC
230
SQYAAYGEKK
240
SRLSNLIKLA
250
QKVPTADLED
260
VLPLAEDITN
270
ILSKCCESAS
280
EDCMAKELPE
290
HTVKLCDNLS
300
TKNSKFEDCC
310
QEKTAMDVFV
320
CTYFMPAAQL
330
PELPDVELPT
340
NKDVCDPGNT
350
KVMDKYTFEL
360
SRRTHLPEVF
370
LSKVLEPTLK
380
SLGECCDVED
390
STTCFNAKGP
400
LLKKELSSFI
410
DKGQELCADY
420
SENTFTEYKK
430
KLAERLKAKL
440
PDATPTELAK
450
LVNKHSDFAS
460
NCCSINSPPL
470
YCDSEIDAEL
KNIL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0072562 | blood microparticle |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0043202 | lysosomal lumen |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:1902118 | calcidiol binding |
| Molecular Function | GO:0140104 | molecular carrier activity |
| Molecular Function | GO:0005499 | vitamin D binding |
| Molecular Function | GO:0090482 | vitamin transmembrane transporter activity |
| Biological Process | GO:0031667 | response to nutrient levels |
| Biological Process | GO:0042359 | vitamin D metabolic process |
| Biological Process | GO:0051180 | vitamin transport |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.