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Overview

Uniprot IDP02787
Protein NameSerotransferrin
Gene NameTF
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
121 YYAVAVVKKDSGFQM
122 YAVAVVKKDSGFQMN
135 MNQLRGKKSCHTGLG
215 SGAFKCLKDGAGDVA
225 AGDVAFVKHSTIFEN
236 IFENLANKADRDQYE
252 LCLDNTRKPVDEYKD
258 RKPVDEYKDCHLAQV
299 HFGKDKSKEFQLFSS
310 LFSSPHGKDLLFKDS
315 HGKDLLFKDSAHGFL
331 VPPRMDAKMYLGYEY
37 VSEHEATKCQSFRDH
373 LSHHERLKCDEWSVN
453 FAIAVVKKSASDLTW
46 QSFRDHMKSVIPSDG
464 DLTWDNLKGKKSCHT
489 PMGLLYNKINHCRFD
508 EGCAPGSKKDSSLCK
509 GCAPGSKKDSSLCKL
553 KGDVAFVKHQTVPQN
564 VPQNTGGKNPDPWAK
571 KNPDPWAKNLNEKDY
576 WAKNLNEKDYELLCL
588 LCLDGTRKPVEEYAN
60 GPSVACVKKASYLDC
61 PSVACVKKASYLDCI
612 AVVTRKDKEACVHKI
618 DKEACVHKILRQQQH
646 CLFRSETKDLLFRDD
659 DDTVCLAKLHDRNTY
668 HDRNTYEKYLGEEYV
676 YLGEEYVKAVGNLRK
683 KAVGNLRKCSTSSLL

Function

Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation

Protein Sequence

10 MRLAVGALLV 20 CAVLGLCLAV 30 PDKTVRWCAV 40 SEHEATKCQS 50 FRDHMKSVIP 60 SDGPSVACVK 70 KASYLDCIRA 80 IAANEADAVT 90 LDAGLVYDAY 100 LAPNNLKPVV 110 AEFYGSKEDP 120 QTFYYAVAVV 130 KKDSGFQMNQ 140 LRGKKSCHTG 150 LGRSAGWNIP 160 IGLLYCDLPE 170 PRKPLEKAVA 180 NFFSGSCAPC 190 ADGTDFPQLC 200 QLCPGCGCST 210 LNQYFGYSGA 220 FKCLKDGAGD 230 VAFVKHSTIF 240 ENLANKADRD 250 QYELLCLDNT 260 RKPVDEYKDC 270 HLAQVPSHTV 280 VARSMGGKED 290 LIWELLNQAQ 300 EHFGKDKSKE 310 FQLFSSPHGK 320 DLLFKDSAHG 330 FLKVPPRMDA 340 KMYLGYEYVT 350 AIRNLREGTC 360 PEAPTDECKP 370 VKWCALSHHE 380 RLKCDEWSVN 390 SVGKIECVSA 400 ETTEDCIAKI 410 MNGEADAMSL 420 DGGFVYIAGK 430 CGLVPVLAEN 440 YNKSDNCEDT 450 PEAGYFAIAV 460 VKKSASDLTW 470 DNLKGKKSCH 480 TAVGRTAGWN 490 IPMGLLYNKI 500 NHCRFDEFFS 510 EGCAPGSKKD 520 SSLCKLCMGS 530 GLNLCEPNNK 540 EGYYGYTGAF 550 RCLVEKGDVA 560 FVKHQTVPQN 570 TGGKNPDPWA 580 KNLNEKDYEL 590 LCLDGTRKPV 600 EEYANCHLAR 610 APNHAVVTRK 620 DKEACVHKIL 630 RQQQHLFGSN 640 VTDCSGNFCL 650 FRSETKDLLF 660 RDDTVCLAKL 670 HDRNTYEKYL 680 GEEYVKAVGN 690 LRKCSTSSLL EACTFRRP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016324 apical plasma membrane
Biological Process GO:0048260 positive regulation of receptor-mediated endocytosis
Biological Process GO:0031647 regulation of protein stability
Cellular Component GO:0045178 basal part of cell
Cellular Component GO:0009925 basal plasma membrane
Cellular Component GO:0072562 blood microparticle
Cellular Component GO:0009986 cell surface
Cellular Component GO:0030669 clathrin-coated endocytic vesicle membrane
Cellular Component GO:0005905 clathrin-coated pit
Cellular Component GO:0031410 cytoplasmic vesicle
Cellular Component GO:0005769 early endosome
Cellular Component GO:0030139 endocytic vesicle
Cellular Component GO:0005788 endoplasmic reticulum lumen
Cellular Component GO:0010008 endosome membrane
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:1990712 HFE-transferrin receptor complex
Cellular Component GO:0005770 late endosome
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0055037 recycling endosome
Cellular Component GO:0034774 secretory granule lumen
Cellular Component GO:0031982 vesicle
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0008199 ferric iron binding
Molecular Function GO:0008198 ferrous iron binding
Molecular Function GO:0034986 iron chaperone activity
Molecular Function GO:1990459 transferrin receptor binding
Molecular Function GO:0044325 transmembrane transporter binding
Biological Process GO:0019731 antibacterial humoral response
Biological Process GO:0007166 cell surface receptor signaling pathway
Biological Process GO:0071281 cellular response to iron ion
Biological Process GO:0006879 intracellular iron ion homeostasis
Biological Process GO:0006826 iron ion transport
Biological Process GO:0060586 multicellular organismal-level iron ion homeostasis
Biological Process GO:0030316 osteoclast differentiation
Biological Process GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.