Search Results
Overview
| Uniprot ID | P02788 |
|---|---|
| Protein Name | Lactotransferrin |
| Gene Name | LTF |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 118 | YYAVAVVKKGGSFQL |
| 262 | RKPVDKFKDCHLARV |
| 304 | FGKDKSPKFQLFGSP |
| 315 | FGSPSGQKDLLFKDS |
| 320 | GQKDLLFKDSAIGFS |
| 352 | TAIQNLRKSEEEVAA |
| 565 | AGDVAFVKDVTVLQN |
| 629 | MDKVERLKQVLLHQQ |
| 638 | VLLHQQAKFGRNGSD |
| 680 | HGKTTYEKYLGPQYV |
| 694 | VAGITNLKKCSTSPL |
Function
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate
Protein Sequence
10
MKLVFLVLLF
20
LGALGLCLAG
30
RRRSVQWCAV
40
SQPEATKCFQ
50
WQRNMRKVRG
60
PPVSCIKRDS
70
PIQCIQAIAE
80
NRADAVTLDG
90
GFIYEAGLAP
100
YKLRPVAAEV
110
YGTERQPRTH
120
YYAVAVVKKG
130
GSFQLNELQG
140
LKSCHTGLRR
150
TAGWNVPIGT
160
LRPFLNWTGP
170
PEPIEAAVAR
180
FFSASCVPGA
190
DKGQFPNLCR
200
LCAGTGENKC
210
AFSSQEPYFS
220
YSGAFKCLRD
230
GAGDVAFIRE
240
STVFEDLSDE
250
AERDEYELLC
260
PDNTRKPVDK
270
FKDCHLARVP
280
SHAVVARSVN
290
GKEDAIWNLL
300
RQAQEKFGKD
310
KSPKFQLFGS
320
PSGQKDLLFK
330
DSAIGFSRVP
340
PRIDSGLYLG
350
SGYFTAIQNL
360
RKSEEEVAAR
370
RARVVWCAVG
380
EQELRKCNQW
390
SGLSEGSVTC
400
SSASTTEDCI
410
ALVLKGEADA
420
MSLDGGYVYT
430
AGKCGLVPVL
440
AENYKSQQSS
450
DPDPNCVDRP
460
VEGYLAVAVV
470
RRSDTSLTWN
480
SVKGKKSCHT
490
AVDRTAGWNI
500
PMGLLFNQTG
510
SCKFDEYFSQ
520
SCAPGSDPRS
530
NLCALCIGDE
540
QGENKCVPNS
550
NERYYGYTGA
560
FRCLAENAGD
570
VAFVKDVTVL
580
QNTDGNNNEA
590
WAKDLKLADF
600
ALLCLDGKRK
610
PVTEARSCHL
620
AMAPNHAVVS
630
RMDKVERLKQ
640
VLLHQQAKFG
650
RNGSDCPDKF
660
CLFQSETKNL
670
LFNDNTECLA
680
RLHGKTTYEK
690
YLGPQYVAGI
700
TNLKKCSTSP
710
LLEACEFLRK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0097013 | phagocytic vesicle lumen |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0055037 | recycling endosome |
| Cellular Component | GO:0030141 | secretory granule |
| Cellular Component | GO:0042581 | specific granule |
| Cellular Component | GO:0035580 | specific granule lumen |
| Cellular Component | GO:1904724 | tertiary granule lumen |
| Molecular Function | GO:0004869 | cysteine-type endopeptidase inhibitor activity |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0008201 | heparin binding |
| Molecular Function | GO:0005506 | iron ion binding |
| Molecular Function | GO:0001530 | lipopolysaccharide binding |
| Molecular Function | GO:0140912 | membrane destabilizing activity |
| Molecular Function | GO:0043539 | protein serine/threonine kinase activator activity |
| Molecular Function | GO:0004252 | serine-type endopeptidase activity |
| Biological Process | GO:0019731 | antibacterial humoral response |
| Biological Process | GO:0019732 | antifungal humoral response |
| Biological Process | GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide |
| Biological Process | GO:0060349 | bone morphogenesis |
| Biological Process | GO:0050829 | defense response to Gram-negative bacterium |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0044828 | host-mediated suppression of viral genome replication |
| Biological Process | GO:0044793 | host-mediated suppression of viral proces |
| Biological Process | GO:0006959 | humoral immune response |
| Biological Process | GO:0002227 | innate immune response in mucosa |
| Biological Process | GO:0006826 | iron ion transport |
| Biological Process | GO:0031640 | killing of cells of another organism |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0031665 | negative regulation of lipopolysaccharide-mediated signaling pathway |
| Biological Process | GO:2001205 | negative regulation of osteoclast development |
| Biological Process | GO:1900229 | negative regulation of single-species biofilm formation in or on host organism |
| Biological Process | GO:2000308 | negative regulation of tumor necrosis factor (ligand) superfamily member 11 production |
| Biological Process | GO:0001503 | ossification |
| Biological Process | GO:1900159 | positive regulation of bone mineralization involved in bone maturation |
| Biological Process | GO:0043123 | positive regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:1902732 | positive regulation of chondrocyte proliferation |
| Biological Process | GO:0045669 | positive regulation of osteoblast differentiation |
| Biological Process | GO:0033690 | positive regulation of osteoblast proliferation |
| Biological Process | GO:0034145 | positive regulation of toll-like receptor 4 signaling pathway |
| Biological Process | GO:0006508 | proteolysis |
| Biological Process | GO:0001817 | regulation of cytokine production |
| Biological Process | GO:0032680 | regulation of tumor necrosis factor production |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.