Search Results
Overview
| Uniprot ID | P02790 |
|---|---|
| Protein Name | Hemopexin |
| Gene Name | HPX |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 112 | HNSVFLIKGDKVWVY |
| 123 | VWVYPPEKKEKGYPK |
| 343 | TLVSGYPKRLEKEVG |
| 402 | ELPWPHEKVDGALCM |
| 411 | DGALCMEKSLGPNSC |
| 91 | ELISERWKNFPSPVD |
Function
Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation
Protein Sequence
10
MARVLGAPVA
20
LGLWSLCWSL
30
AIATPLPPTS
40
AHGNVAEGET
50
KPDPDVTERC
60
SDGWSFDATT
70
LDDNGTMLFF
80
KGEFVWKSHK
90
WDRELISERW
100
KNFPSPVDAA
110
FRQGHNSVFL
120
IKGDKVWVYP
130
PEKKEKGYPK
140
LLQDEFPGIP
150
SPLDAAVECH
160
RGECQAEGVL
170
FFQGDREWFW
180
DLATGTMKER
190
SWPAVGNCSS
200
ALRWLGRYYC
210
FQGNQFLRFD
220
PVRGEVPPRY
230
PRDVRDYFMP
240
CPGRGHGHRN
250
GTGHGNSTHH
260
GPEYMRCSPH
270
LVLSALTSDN
280
HGATYAFSGT
290
HYWRLDTSRD
300
GWHSWPIAHQ
310
WPQGPSAVDA
320
AFSWEEKLYL
330
VQGTQVYVFL
340
TKGGYTLVSG
350
YPKRLEKEVG
360
TPHGIILDSV
370
DAAFICPGSS
380
RLHIMAGRRL
390
WWLDLKSGAQ
400
ATWTELPWPH
410
EKVDGALCME
420
KSLGPNSCSA
430
NGPGLYLIHG
440
PNLYCYSDVE
450
KLNAAKALPQ
460
PQNVTSLLGC
TH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0072562 | blood microparticle |
| Cellular Component | GO:0071682 | endocytic vesicle lumen |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Molecular Function | GO:0015232 | heme transmembrane transporter activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0042168 | heme metabolic process |
| Biological Process | GO:0015886 | heme transport |
| Biological Process | GO:0006879 | intracellular iron ion homeostasis |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.