Search Results

Overview

Uniprot IDP02792
Protein NameFerritin light chain
Gene NameFTL
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
105 KAAMALEKKLNQALL
106 AAMALEKKLNQALLD
144 EEVKLIKKMGDHLTN
59 FRELAEEKREGYERL
68 EGYERLLKMQNQRGG
83 RALFQDIKKPAEDEW
84 ALFQDIKKPAEDEWG
92 PAEDEWGKTPDAMKA
98 GKTPDAMKAAMALEK

Function

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Delivery to lysosomes by the cargo receptor NCOA4 for autophagic degradation and release or iron (PubMed:24695223)

Protein Sequence

10 MSSQIRQNYS 20 TDVEAAVNSL 30 VNLYLQASYT 40 YLSLGFYFDR 50 DDVALEGVSH 60 FFRELAEEKR 70 EGYERLLKMQ 80 NQRGGRALFQ 90 DIKKPAEDEW 100 GKTPDAMKAA 110 MALEKKLNQA 120 LLDLHALGSA 130 RTDPHLCDFL 140 ETHFLDEEVK 150 LIKKMGDHLT 160 NLHRLGGPEA 170 GLGEYLFERL TLKHD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0044754 autolysosome
Cellular Component GO:0005776 autophagosome
Cellular Component GO:0035578 azurophil granule lumen
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0070288 ferritin complex
Cellular Component GO:0016020 membrane
Molecular Function GO:0008199 ferric iron binding
Molecular Function GO:0008198 ferrous iron binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0005506 iron ion binding
Biological Process GO:0006879 intracellular iron ion homeostasis
Biological Process GO:0006826 iron ion transport

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[3] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.