Search Results
Overview
| Uniprot ID | P02793 |
|---|---|
| Protein Name | Ferritin light chain 1 |
| Gene Name | Ftl1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 144 | KEVKLIKKMGNHLTN |
Function
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Delivery to lysosomes by the cargo receptor NCOA4 for autophagic degradation and release or iron (By similarity)
Protein Sequence
10
MTSQIRQNYS
20
TEVEAAVNRL
30
VNLHLRASYT
40
YLSLGFFFDR
50
DDVALEGVGH
60
FFRELAEEKR
70
EGAERLLKLQ
80
NERGGRALFQ
90
DVQKPSQDEW
100
GKTLEAMEAA
110
LALEKNLNQA
120
LLDLHALGSA
130
RTDPHLCDFL
140
ESHFLDKEVK
150
LIKKMGNHLT
160
NLRRVAGPQP
170
AQTGVAQASL
180
GEYLFERLTL
KHD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0044754 | autolysosome |
| Cellular Component | GO:0005776 | autophagosome |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0070288 | ferritin complex |
| Molecular Function | GO:0008199 | ferric iron binding |
| Molecular Function | GO:0008198 | ferrous iron binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0005506 | iron ion binding |
| Biological Process | GO:0006879 | intracellular iron ion homeostasis |
| Biological Process | GO:0006826 | iron ion transport |
| Biological Process | GO:0010288 | response to lead ion |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.