Search Results
Overview
| Uniprot ID | P02794 |
|---|---|
| Protein Name | Ferritin heavy chain |
| Gene Name | FTH1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 120 | QSLLELHKLATDKND |
| 125 | LHKLATDKNDPHLCD |
| 144 | HYLNEQVKAIKELGD |
| 147 | NEQVKAIKELGDHVT |
| 158 | DHVTNLRKMGAPESG |
| 54 | VALKNFAKYFLHQSH |
| 69 | EEREHAEKLMKLQNQ |
| 72 | EHAEKLMKLQNQRGG |
Function
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity (PubMed:9003196). Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (PubMed:9003196). Also plays a role in delivery of iron to cells (By similarity). Mediates iron uptake in capsule cells of the developing kidney (By similarity). Delivery to lysosomes is mediated by the cargo receptor NCOA4 for autophagic degradation and release of iron (PubMed:24695223, PubMed:26436293)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0044754 | autolysosome |
| Cellular Component | GO:0005776 | autophagosome |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0070288 | ferritin complex |
| Cellular Component | GO:1904813 | ficolin-1-rich granule lumen |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:1904724 | tertiary granule lumen |
| Molecular Function | GO:0008199 | ferric iron binding |
| Molecular Function | GO:0008198 | ferrous iron binding |
| Molecular Function | GO:0004322 | ferroxidase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0005506 | iron ion binding |
| Molecular Function | GO:0140315 | iron ion sequestering activity |
| Biological Process | GO:0006955 | immune response |
| Biological Process | GO:0006879 | intracellular iron ion homeostasis |
| Biological Process | GO:0006826 | iron ion transport |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0110076 | negative regulation of ferroptosis |
| Biological Process | GO:0048147 | negative regulation of fibroblast proliferation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[3] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.
[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[5] Hu J, Jin Z, Gao Y, Liu Q, Yu Y et al.. Global Profiling of Lactylation Proteomics and Specific Lactylated Site Validation in Rheumatoid Arthritis Patients.. J Proteome Res 24(4):1732-1744. 2025 Apr 4. PMID: 40112136.