Search Results
Overview
| Uniprot ID | P03956 |
|---|---|
| Protein Name | Interstitial collagenase |
| Gene Name | MMP1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 459 | KRILTLQKANSWFNC |
Function
Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X (PubMed:1645757, PubMed:2153297, PubMed:2557822). In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity (PubMed:16807369)
Protein Sequence
10
MHSFPPLLLL
20
LFWGVVSHSF
30
PATLETQEQD
40
VDLVQKYLEK
50
YYNLKNDGRQ
60
VEKRRNSGPV
70
VEKLKQMQEF
80
FGLKVTGKPD
90
AETLKVMKQP
100
RCGVPDVAQF
110
VLTEGNPRWE
120
QTHLTYRIEN
130
YTPDLPRADV
140
DHAIEKAFQL
150
WSNVTPLTFT
160
KVSEGQADIM
170
ISFVRGDHRD
180
NSPFDGPGGN
190
LAHAFQPGPG
200
IGGDAHFDED
210
ERWTNNFREY
220
NLHRVAAHEL
230
GHSLGLSHST
240
DIGALMYPSY
250
TFSGDVQLAQ
260
DDIDGIQAIY
270
GRSQNPVQPI
280
GPQTPKACDS
290
KLTFDAITTI
300
RGEVMFFKDR
310
FYMRTNPFYP
320
EVELNFISVF
330
WPQLPNGLEA
340
AYEFADRDEV
350
RFFKGNKYWA
360
VQGQNVLHGY
370
PKDIYSSFGF
380
PRTVKHIDAA
390
LSEENTGKTY
400
FFVANKYWRY
410
DEYKRSMDPG
420
YPKMIAHDFP
430
GIGHKVDAVF
440
MKDGFFYFFH
450
GTRQYKFDPK
460
TKRILTLQKA
NSWFNCRKN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005576 | extracellular region |
| Molecular Function | GO:0004175 | endopeptidase activity |
| Molecular Function | GO:0004222 | metalloendopeptidase activity |
| Molecular Function | GO:0008233 | peptidase activity |
| Molecular Function | GO:0004252 | serine-type endopeptidase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0071492 | cellular response to UV-A |
| Biological Process | GO:0030574 | collagen catabolic process |
| Biological Process | GO:0022617 | extracellular matrix disassembly |
| Biological Process | GO:0030198 | extracellular matrix organization |
| Biological Process | GO:0031334 | positive regulation of protein-containing complex assembly |
| Biological Process | GO:0006508 | proteolysis |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.