Overview
| Uniprot ID | P03973 |
|---|
| Protein Name | Antileukoproteinase |
|---|
| Gene Name | SLPI |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 112 |
CEMDGQCKRDLKCCM |
| 124 |
CCMGMCGKSCVSPVK |
| 131 |
KSCVSPVKA****** |
| 39 |
AGVCPPKKSAQCLRY |
| 47 |
SAQCLRYKKPECQSD |
Function
Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G (PubMed:10702419, PubMed:2039600, PubMed:2110563, PubMed:24121345, PubMed:3462719, PubMed:3533531). Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses (PubMed:10702419, PubMed:24352879). Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for normal resistance to infection by L.major. Required for normal wound healing, probably by preventing tissue damage by limiting protease activity (By similarity). Together with ELANE, required for normal differentiation and proliferation of bone marrow myeloid cells (PubMed:24352879)
Protein Sequence
10
MKSSGLFPFL
20
VLLALGTLAP
30
WAVEGSGKSF
40
KAGVCPPKKS
50
AQCLRYKKPE
60
CQSDWQCPGK
70
KRCCPDTCGI
80
KCLDPVDTPN
90
PTRRKPGKCP
100
VTYGQCLMLN
110
PPNFCEMDGQ
120
CKRDLKCCMG
130
MCGKSCVSPV
KA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0031012 |
extracellular matrix |
| Cellular Component |
GO:0005576 |
extracellular region |
| Cellular Component |
GO:0005615 |
extracellular space |
| Cellular Component |
GO:0035580 |
specific granule lumen |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0004866 |
endopeptidase inhibitor activity |
| Molecular Function |
GO:0019899 |
enzyme binding |
| Molecular Function |
GO:0003729 |
mRNA binding |
| Molecular Function |
GO:0004867 |
serine-type endopeptidase inhibitor activity |
| Biological Process |
GO:0019731 |
antibacterial humoral response |
| Biological Process |
GO:0051851 |
host-mediated perturbation of symbiont process |
| Biological Process |
GO:0006955 |
immune response |
| Biological Process |
GO:0045087 |
innate immune response |
| Biological Process |
GO:0032091 |
negative regulation of protein binding |
| Biological Process |
GO:0045071 |
negative regulation of viral genome replication |
| Biological Process |
GO:0032496 |
response to lipopolysaccharide |
Reference
[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.