Search Results
Overview
| Uniprot ID | P03994 |
|---|---|
| Protein Name | Hyaluronan and proteoglycan link protein 1 |
| Gene Name | Hapln1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 103 | VSMGYHKKTYGGYQG |
| 48 | LVEAEQAKVFSHRGG |
Function
Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix
Protein Sequence
10
MRSLLFLVLI
20
SVCRADHLSD
30
SYTPDQDRVI
40
HIQAENGPRL
50
LVEAEQAKVF
60
SHRGGNVTLP
70
CKFYRDPTAF
80
GSGIHKIRIK
90
WTKLTSDYLR
100
EVDVFVSMGY
110
HKKTYGGYQG
120
RVFLKGGSDN
130
DASLIITDLT
140
LEDYGRYKCE
150
VIEGLEDDTA
160
VVALELQGVV
170
FPYFPRLGRY
180
NLNFHEARQA
190
CLDQDAVIAS
200
FDQLYDAWRG
210
GLDWCNAGWL
220
SDGSVQYPIT
230
KPREPCGGQN
240
TVPGVRNYGF
250
WDKDKSRYDV
260
FCFTSNFNGR
270
FYYLIHPTKL
280
TYDEAVQACL
290
NDGAQIAKVG
300
QIFAAWKLLG
310
YDRCDAGWLA
320
DGSVRYPISR
330
PRRRCSPTEA
340
AVRFVGFPDK
350
KHKLYGVYCF
RAYN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0140150 | gel phase of interstitial matrix |
| Cellular Component | GO:0072534 | perineuronal net |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0005540 | hyaluronic acid binding |
| Molecular Function | GO:0005198 | structural molecule activity |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0007417 | central nervous system development |
| Biological Process | GO:0001501 | skeletal system development |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.