Search Results
Overview
| Uniprot ID | P04003 |
|---|---|
| Protein Name | C4b-binding protein alpha chain |
| Gene Name | C4BPA |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 78 | FKTGTTLKYTCLPGY |
Function
Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It also interacts with anticoagulant protein S and with serum amyloid P component
Protein Sequence
10
MHPPKTPSGA
20
LHRKRKMAAW
30
PFSRLWKVSD
40
PILFQMTLIA
50
ALLPAVLGNC
60
GPPPTLSFAA
70
PMDITLTETR
80
FKTGTTLKYT
90
CLPGYVRSHS
100
TQTLTCNSDG
110
EWVYNTFCIY
120
KRCRHPGELR
130
NGQVEIKTDL
140
SFGSQIEFSC
150
SEGFFLIGST
160
TSRCEVQDRG
170
VGWSHPLPQC
180
EIVKCKPPPD
190
IRNGRHSGEE
200
NFYAYGFSVT
210
YSCDPRFSLL
220
GHASISCTVE
230
NETIGVWRPS
240
PPTCEKITCR
250
KPDVSHGEMV
260
SGFGPIYNYK
270
DTIVFKCQKG
280
FVLRGSSVIH
290
CDADSKWNPS
300
PPACEPNSCI
310
NLPDIPHASW
320
ETYPRPTKED
330
VYVVGTVLRY
340
RCHPGYKPTT
350
DEPTTVICQK
360
NLRWTPYQGC
370
EALCCPEPKL
380
NNGEITQHRK
390
SRPANHCVYF
400
YGDEISFSCH
410
ETSRFSAICQ
420
GDGTWSPRTP
430
SCGDICNFPP
440
KIAHGHYKQS
450
SSYSFFKEEI
460
IYECDKGYIL
470
VGQAKLSCSY
480
SHWSAPAPQC
490
KALCRKPELV
500
NGRLSVDKDQ
510
YVEPENVTIQ
520
CDSGYGVVGP
530
QSITCSGNRT
540
WYPEVPKCEW
550
ETPEGCEQVL
560
TGKRLMQCLP
570
NPEDVKMALE
580
VYKLSLEIEQ
590
LELQRDSARQ
STLDKEL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0072562 | blood microparticle |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0006958 | complement activation, classical pathway |
| Biological Process | GO:0045087 | innate immune response |
| Biological Process | GO:0045959 | negative regulation of complement activation, classical pathway |
| Biological Process | GO:0045732 | positive regulation of protein catabolic process |
| Biological Process | GO:1903027 | regulation of opsonization |
| Biological Process | GO:0009609 | response to symbiotic bacterium |
| Biological Process | GO:0002456 | T cell mediated immunity |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.