Search Results
Overview
| Uniprot ID | P04004 |
|---|---|
| Protein Name | Vitronectin |
| Gene Name | VTN |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 186 | YCYELDEKAVRPGYP |
| 194 | AVRPGYPKLIRDVWG |
| 218 | TRINCQGKTYLFKGS |
| 223 | QGKTYLFKGSQYWRF |
Function
Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway
Protein Sequence
10
MAPLRPLLIL
20
ALLAWVALAD
30
QESCKGRCTE
40
GFNVDKKCQC
50
DELCSYYQSC
60
CTDYTAECKP
70
QVTRGDVFTM
80
PEDEYTVYDD
90
GEEKNNATVH
100
EQVGGPSLTS
110
DLQAQSKGNP
120
EQTPVLKPEE
130
EAPAPEVGAS
140
KPEGIDSRPE
150
TLHPGRPQPP
160
AEEELCSGKP
170
FDAFTDLKNG
180
SLFAFRGQYC
190
YELDEKAVRP
200
GYPKLIRDVW
210
GIEGPIDAAF
220
TRINCQGKTY
230
LFKGSQYWRF
240
EDGVLDPDYP
250
RNISDGFDGI
260
PDNVDAALAL
270
PAHSYSGRER
280
VYFFKGKQYW
290
EYQFQHQPSQ
300
EECEGSSLSA
310
VFEHFAMMQR
320
DSWEDIFELL
330
FWGRTSAGTR
340
QPQFISRDWH
350
GVPGQVDAAM
360
AGRIYISGMA
370
PRPSLAKKQR
380
FRHRNRKGYR
390
SQRGHSRGRN
400
QNSRRPSRAT
410
WLSLFSSEES
420
NLGANNYDDY
430
RMDWLVPATC
440
EPIQSVFFFS
450
GDKYYRVNLR
460
TRRVDTVDPP
470
YPRSIAQYWL
GCPAPGHL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0071062 | alphav-beta3 integrin-vitronectin complex |
| Cellular Component | GO:0005604 | basement membrane |
| Cellular Component | GO:0072562 | blood microparticle |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005796 | Golgi lumen |
| Cellular Component | GO:0001527 | microfibril |
| Cellular Component | GO:0048237 | rough endoplasmic reticulum lumen |
| Cellular Component | GO:0020003 | symbiont-containing vacuole |
| Molecular Function | GO:0005518 | collagen binding |
| Molecular Function | GO:0050840 | extracellular matrix binding |
| Molecular Function | GO:0005201 | extracellular matrix structural constituent |
| Molecular Function | GO:0008201 | heparin binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0005178 | integrin binding |
| Molecular Function | GO:0030247 | polysaccharide binding |
| Molecular Function | GO:0005044 | scavenger receptor activity |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0033627 | cell adhesion mediated by integrin |
| Biological Process | GO:0016477 | cell migration |
| Biological Process | GO:0007160 | cell-matrix adhesion |
| Biological Process | GO:0035987 | endodermal cell differentiation |
| Biological Process | GO:0006955 | immune response |
| Biological Process | GO:0007229 | integrin-mediated signaling pathway |
| Biological Process | GO:0097421 | liver regeneration |
| Biological Process | GO:0030195 | negative regulation of blood coagulation |
| Biological Process | GO:0051918 | negative regulation of fibrinolysis |
| Biological Process | GO:0045861 | negative regulation of proteolysis |
| Biological Process | GO:0048709 | oligodendrocyte differentiation |
| Biological Process | GO:2001046 | positive regulation of integrin-mediated signaling pathway |
| Biological Process | GO:0048260 | positive regulation of receptor-mediated endocytosis |
| Biological Process | GO:0014911 | positive regulation of smooth muscle cell migration |
| Biological Process | GO:0030949 | positive regulation of vascular endothelial growth factor receptor signaling pathway |
| Biological Process | GO:1900748 | positive regulation of vascular endothelial growth factor signaling pathway |
| Biological Process | GO:0090303 | positive regulation of wound healing |
| Biological Process | GO:0051258 | protein polymerization |
| Biological Process | GO:0030155 | regulation of cell adhesion |
| Biological Process | GO:0061302 | smooth muscle cell-matrix adhesion |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.