Search Results

Overview

Uniprot IDP04040
Protein NameCatalase
Gene NameCAT
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
105 KVFEHIGKKTPIAVR
106 VFEHIGKKTPIAVRF
16 SDQMQHWKEQRAAQK
169 PSFIHSQKRNPQTHL
23 KEQRAAQKADVLTTG
233 NGEAVYCKFHYKTDQ
237 VYCKFHYKTDQGIKN
243 YKTDQGIKNLSVEDA
306 LTKVWPHKDYPLIPV
315 YPLIPVGKLVLNRNP
38 AGNPVGDKLNVITVG
468 ENIAGHLKDAQIFIQ
476 DAQIFIQKKAVKNFT
480 FIQKKAVKNFTEVHP
499 HIQALLDKYNAEKPK
504 LDKYNAEKPKNAIHT
506 KYNAEKPKNAIHTFV
77 PERVVHAKGAGAFGY
93 EVTHDITKYSKAKVF
98 ITKYSKAKVFEHIGK

Function

Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide (PubMed:7882369). Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells (PubMed:7882369)

Protein Sequence

10 MADSRDPASD 20 QMQHWKEQRA 30 AQKADVLTTG 40 AGNPVGDKLN 50 VITVGPRGPL 60 LVQDVVFTDE 70 MAHFDRERIP 80 ERVVHAKGAG 90 AFGYFEVTHD 100 ITKYSKAKVF 110 EHIGKKTPIA 120 VRFSTVAGES 130 GSADTVRDPR 140 GFAVKFYTED 150 GNWDLVGNNT 160 PIFFIRDPIL 170 FPSFIHSQKR 180 NPQTHLKDPD 190 MVWDFWSLRP 200 ESLHQVSFLF 210 SDRGIPDGHR 220 HMNGYGSHTF 230 KLVNANGEAV 240 YCKFHYKTDQ 250 GIKNLSVEDA 260 ARLSQEDPDY 270 GIRDLFNAIA 280 TGKYPSWTFY 290 IQVMTFNQAE 300 TFPFNPFDLT 310 KVWPHKDYPL 320 IPVGKLVLNR 330 NPVNYFAEVE 340 QIAFDPSNMP 350 PGIEASPDKM 360 LQGRLFAYPD 370 THRHRLGPNY 380 LHIPVNCPYR 390 ARVANYQRDG 400 PMCMQDNQGG 410 APNYYPNSFG 420 APEQQPSALE 430 HSIQYSGEVR 440 RFNTANDDNV 450 TQVRAFYVNV 460 LNEEQRKRLC 470 ENIAGHLKDA 480 QIFIQKKAVK 490 NFTEVHPDYG 500 SHIQALLDKY 510 NAEKPKNAIH 520 TFVQSGSHLA AREKANL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:1904813 ficolin-1-rich granule lumen
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0016020 membrane
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005782 peroxisomal matrix
Cellular Component GO:0005778 peroxisomal membrane
Cellular Component GO:0005777 peroxisome
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0034774 secretory granule lumen
Molecular Function GO:0004046 aminoacylase activity
Molecular Function GO:0016209 antioxidant activity
Molecular Function GO:0004096 catalase activity
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0020037 heme binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0050661 NADP binding
Molecular Function GO:0016684 oxidoreductase activity, acting on peroxide as acceptor
Molecular Function GO:0042803 protein homodimerization activity
Biological Process GO:0061692 cellular detoxification of hydrogen peroxide
Biological Process GO:0071363 cellular response to growth factor stimulus
Biological Process GO:0042744 hydrogen peroxide catabolic process
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0001649 osteoblast differentiation
Biological Process GO:0051781 positive regulation of cell division
Biological Process GO:0014823 response to activity
Biological Process GO:0072722 response to amitrole
Biological Process GO:0046686 response to cadmium ion
Biological Process GO:0032355 response to estradiol
Biological Process GO:0045471 response to ethanol
Biological Process GO:0070542 response to fatty acid
Biological Process GO:0042542 response to hydrogen peroxide
Biological Process GO:0055093 response to hyperoxia
Biological Process GO:0001666 response to hypoxia
Biological Process GO:0014854 response to inactivity
Biological Process GO:0032868 response to insulin
Biological Process GO:0033591 response to L-ascorbic acid
Biological Process GO:0010288 response to lead ion
Biological Process GO:0009642 response to light intensity
Biological Process GO:0010193 response to ozone
Biological Process GO:0080184 response to phenylpropanoid
Biological Process GO:0000302 response to reactive oxygen species
Biological Process GO:0033189 response to vitamin A
Biological Process GO:0033197 response to vitamin E
Biological Process GO:0009410 response to xenobiotic stimulus
Biological Process GO:0001657 ureteric bud development
Biological Process GO:0009650 UV protection

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.