Search Results

Overview

Uniprot IDP04114
Protein NameApolipoprotein B-100
Gene NameAPOB
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
100 KTSQCTLKEVYGFNP
1121 TKEERKIKGVISIPR
1163 AYGSTVSKRVAWHYD
1324 RTPALHFKSVGFHLP
1429 CDGSLRHKFLDSNIK
1442 IKFSHVEKLGNNPVS
1482 KKQHLFVKEVKIDGQ
1579 SDTNGKYKNFATSNK
1778 DNIYSSDKFYKQTVN
1958 SHHLVSRKSISAALE
2100 ENVQRNLKHINIDQF
2141 QVSHAKEKLTALTKK
2284 DIQHLAGKLKQHIEA
2286 QHLAGKLKQHIEAID
2369 VELAHQYKLKETIQK
254 YTLDAKRKHVAEAIC
275 LPFSYKNKYGMVAQV
2897 FHKLNIPKLDFSSQA
3028 HDAHLNGKVIGTLKN
304 RFFGEGTKKMGLAFE
3237 FDKYKAEKSHDELPR
333 LKTLQELKKLTISEQ
4132 DIDVRFQKAASGTTG
4145 TGTYQEWKDKAQNLY
4185 VTQEFHMKVKHLIDS
4261 PFELRKHKLIDVISM
4278 ELLKDLSKEAQEVFK
4291 FKAIQSLKTTEVLRN
4498 YHQQFRYKLQDFSDQ
51 TRFKHLRKYTYNYEA
641 SRNYQLYKSVSLPSL
934 PSPKRPVKLLSGGNT

Function

Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor

Protein Sequence

10 MDPPRPALLA 20 LLALPALLLL 30 LLAGARAEEE 40 MLENVSLVCP 50 KDATRFKHLR 60 KYTYNYEAES 70 SSGVPGTADS 80 RSATRINCKV 90 ELEVPQLCSF 100 ILKTSQCTLK 110 EVYGFNPEGK 120 ALLKKTKNSE 130 EFAAAMSRYE 140 LKLAIPEGKQ 150 VFLYPEKDEP 160 TYILNIKRGI 170 ISALLVPPET 180 EEAKQVLFLD 190 TVYGNCSTHF 200 TVKTRKGNVA 210 TEISTERDLG 220 QCDRFKPIRT 230 GISPLALIKG 240 MTRPLSTLIS 250 SSQSCQYTLD 260 AKRKHVAEAI 270 CKEQHLFLPF 280 SYKNKYGMVA 290 QVTQTLKLED 300 TPKINSRFFG 310 EGTKKMGLAF 320 ESTKSTSPPK 330 QAEAVLKTLQ 340 ELKKLTISEQ 350 NIQRANLFNK 360 LVTELRGLSD 370 EAVTSLLPQL 380 IEVSSPITLQ 390 ALVQCGQPQC 400 STHILQWLKR 410 VHANPLLIDV 420 VTYLVALIPE 430 PSAQQLREIF 440 NMARDQRSRA 450 TLYALSHAVN 460 NYHKTNPTGT 470 QELLDIANYL 480 MEQIQDDCTG 490 DEDYTYLILR 500 VIGNMGQTME 510 QLTPELKSSI 520 LKCVQSTKPS 530 LMIQKAAIQA 540 LRKMEPKDKD 550 QEVLLQTFLD 560 DASPGDKRLA 570 AYLMLMRSPS 580 QADINKIVQI 590 LPWEQNEQVK 600 NFVASHIANI 610 LNSEELDIQD 620 LKKLVKEALK 630 ESQLPTVMDF 640 RKFSRNYQLY 650 KSVSLPSLDP 660 ASAKIEGNLI 670 FDPNNYLPKE 680 SMLKTTLTAF 690 GFASADLIEI 700 GLEGKGFEPT 710 LEALFGKQGF 720 FPDSVNKALY 730 WVNGQVPDGV 740 SKVLVDHFGY 750 TKDDKHEQDM 760 VNGIMLSVEK 770 LIKDLKSKEV 780 PEARAYLRIL 790 GEELGFASLH 800 DLQLLGKLLL 810 MGARTLQGIP 820 QMIGEVIRKG 830 SKNDFFLHYI 840 FMENAFELPT 850 GAGLQLQISS 860 SGVIAPGAKA 870 GVKLEVANMQ 880 AELVAKPSVS 890 VEFVTNMGII 900 IPDFARSGVQ 910 MNTNFFHESG 920 LEAHVALKAG 930 KLKFIIPSPK 940 RPVKLLSGGN 950 TLHLVSTTKT 960 EVIPPLIENR 970 QSWSVCKQVF 980 PGLNYCTSGA 990 YSNASSTDSA 1000 SYYPLTGDTR 1010 LELELRPTGE 1020 IEQYSVSATY 1030 ELQREDRALV 1040 DTLKFVTQAE 1050 GAKQTEATMT 1060 FKYNRQSMTL 1070 SSEVQIPDFD 1080 VDLGTILRVN 1090 DESTEGKTSY 1100 RLTLDIQNKK 1110 ITEVALMGHL 1120 SCDTKEERKI 1130 KGVISIPRLQ 1140 AEARSEILAH 1150 WSPAKLLLQM 1160 DSSATAYGST 1170 VSKRVAWHYD 1180 EEKIEFEWNT 1190 GTNVDTKKMT 1200 SNFPVDLSDY 1210 PKSLHMYANR 1220 LLDHRVPQTD 1230 MTFRHVGSKL 1240 IVAMSSWLQK 1250 ASGSLPYTQT 1260 LQDHLNSLKE 1270 FNLQNMGLPD 1280 FHIPENLFLK 1290 SDGRVKYTLN 1300 KNSLKIEIPL 1310 PFGGKSSRDL 1320 KMLETVRTPA 1330 LHFKSVGFHL 1340 PSREFQVPTF 1350 TIPKLYQLQV 1360 PLLGVLDLST 1370 NVYSNLYNWS 1380 ASYSGGNTST 1390 DHFSLRARYH 1400 MKADSVVDLL 1410 SYNVQGSGET 1420 TYDHKNTFTL 1430 SCDGSLRHKF 1440 LDSNIKFSHV 1450 EKLGNNPVSK 1460 GLLIFDASSS 1470 WGPQMSASVH 1480 LDSKKKQHLF 1490 VKEVKIDGQF 1500 RVSSFYAKGT 1510 YGLSCQRDPN 1520 TGRLNGESNL 1530 RFNSSYLQGT 1540 NQITGRYEDG 1550 TLSLTSTSDL 1560 QSGIIKNTAS 1570 LKYENYELTL 1580 KSDTNGKYKN 1590 FATSNKMDMT 1600 FSKQNALLRS 1610 EYQADYESLR 1620 FFSLLSGSLN 1630 SHGLELNADI 1640 LGTDKINSGA 1650 HKATLRIGQD 1660 GISTSATTNL 1670 KCSLLVLENE 1680 LNAELGLSGA 1690 SMKLTTNGRF 1700 REHNAKFSLD 1710 GKAALTELSL 1720 GSAYQAMILG 1730 VDSKNIFNFK 1740 VSQEGLKLSN 1750 DMMGSYAEMK 1760 FDHTNSLNIA 1770 GLSLDFSSKL 1780 DNIYSSDKFY 1790 KQTVNLQLQP 1800 YSLVTTLNSD 1810 LKYNALDLTN 1820 NGKLRLEPLK 1830 LHVAGNLKGA 1840 YQNNEIKHIY 1850 AISSAALSAS 1860 YKADTVAKVQ 1870 GVEFSHRLNT 1880 DIAGLASAID 1890 MSTNYNSDSL 1900 HFSNVFRSVM 1910 APFTMTIDAH 1920 TNGNGKLALW 1930 GEHTGQLYSK 1940 FLLKAEPLAF 1950 TFSHDYKGST 1960 SHHLVSRKSI 1970 SAALEHKVSA 1980 LLTPAEQTGT 1990 WKLKTQFNNN 2000 EYSQDLDAYN 2010 TKDKIGVELT 2020 GRTLADLTLL 2030 DSPIKVPLLL 2040 SEPINIIDAL 2050 EMRDAVEKPQ 2060 EFTIVAFVKY 2070 DKNQDVHSIN 2080 LPFFETLQEY 2090 FERNRQTIIV 2100 VLENVQRNLK 2110 HINIDQFVRK 2120 YRAALGKLPQ 2130 QANDYLNSFN 2140 WERQVSHAKE 2150 KLTALTKKYR 2160 ITENDIQIAL 2170 DDAKINFNEK 2180 LSQLQTYMIQ 2190 FDQYIKDSYD 2200 LHDLKIAIAN 2210 IIDEIIEKLK 2220 SLDEHYHIRV 2230 NLVKTIHDLH 2240 LFIENIDFNK 2250 SGSSTASWIQ 2260 NVDTKYQIRI 2270 QIQEKLQQLK 2280 RHIQNIDIQH 2290 LAGKLKQHIE 2300 AIDVRVLLDQ 2310 LGTTISFERI 2320 NDILEHVKHF 2330 VINLIGDFEV 2340 AEKINAFRAK 2350 VHELIERYEV 2360 DQQIQVLMDK 2370 LVELAHQYKL 2380 KETIQKLSNV 2390 LQQVKIKDYF 2400 EKLVGFIDDA 2410 VKKLNELSFK 2420 TFIEDVNKFL 2430 DMLIKKLKSF 2440 DYHQFVDETN 2450 DKIREVTQRL 2460 NGEIQALELP 2470 QKAEALKLFL 2480 EETKATVAVY 2490 LESLQDTKIT 2500 LIINWLQEAL 2510 SSASLAHMKA 2520 KFRETLEDTR 2530 DRMYQMDIQQ 2540 ELQRYLSLVG 2550 QVYSTLVTYI 2560 SDWWTLAAKN 2570 LTDFAEQYSI 2580 QDWAKRMKAL 2590 VEQGFTVPEI 2600 KTILGTMPAF 2610 EVSLQALQKA 2620 TFQTPDFIVP 2630 LTDLRIPSVQ 2640 INFKDLKNIK 2650 IPSRFSTPEF 2660 TILNTFHIPS 2670 FTIDFVEMKV 2680 KIIRTIDQML 2690 NSELQWPVPD 2700 IYLRDLKVED 2710 IPLARITLPD 2720 FRLPEIAIPE 2730 FIIPTLNLND 2740 FQVPDLHIPE 2750 FQLPHISHTI 2760 EVPTFGKLYS 2770 ILKIQSPLFT 2780 LDANADIGNG 2790 TTSANEAGIA 2800 ASITAKGESK 2810 LEVLNFDFQA 2820 NAQLSNPKIN 2830 PLALKESVKF 2840 SSKYLRTEHG 2850 SEMLFFGNAI 2860 EGKSNTVASL 2870 HTEKNTLELS 2880 NGVIVKINNQ 2890 LTLDSNTKYF 2900 HKLNIPKLDF 2910 SSQADLRNEI 2920 KTLLKAGHIA 2930 WTSSGKGSWK 2940 WACPRFSDEG 2950 THESQISFTI 2960 EGPLTSFGLS 2970 NKINSKHLRV 2980 NQNLVYESGS 2990 LNFSKLEIQS 3000 QVDSQHVGHS 3010 VLTAKGMALF 3020 GEGKAEFTGR 3030 HDAHLNGKVI 3040 GTLKNSLFFS 3050 AQPFEITAST 3060 NNEGNLKVRF 3070 PLRLTGKIDF 3080 LNNYALFLSP 3090 SAQQASWQVS 3100 ARFNQYKYNQ 3110 NFSAGNNENI 3120 MEAHVGINGE 3130 ANLDFLNIPL 3140 TIPEMRLPYT 3150 IITTPPLKDF 3160 SLWEKTGLKE 3170 FLKTTKQSFD 3180 LSVKAQYKKN 3190 KHRHSITNPL 3200 AVLCEFISQS 3210 IKSFDRHFEK 3220 NRNNALDFVT 3230 KSYNETKIKF 3240 DKYKAEKSHD 3250 ELPRTFQIPG 3260 YTVPVVNVEV 3270 SPFTIEMSAF 3280 GYVFPKAVSM 3290 PSFSILGSDV 3300 RVPSYTLILP 3310 SLELPVLHVP 3320 RNLKLSLPDF 3330 KELCTISHIF 3340 IPAMGNITYD 3350 FSFKSSVITL 3360 NTNAELFNQS 3370 DIVAHLLSSS 3380 SSVIDALQYK 3390 LEGTTRLTRK 3400 RGLKLATALS 3410 LSNKFVEGSH 3420 NSTVSLTTKN 3430 MEVSVATTTK 3440 AQIPILRMNF 3450 KQELNGNTKS 3460 KPTVSSSMEF 3470 KYDFNSSMLY 3480 STAKGAVDHK 3490 LSLESLTSYF 3500 SIESSTKGDV 3510 KGSVLSREYS 3520 GTIASEANTY 3530 LNSKSTRSSV 3540 KLQGTSKIDD 3550 IWNLEVKENF 3560 AGEATLQRIY 3570 SLWEHSTKNH 3580 LQLEGLFFTN 3590 GEHTSKATLE 3600 LSPWQMSALV 3610 QVHASQPSSF 3620 HDFPDLGQEV 3630 ALNANTKNQK 3640 IRWKNEVRIH 3650 SGSFQSQVEL 3660 SNDQEKAHLD 3670 IAGSLEGHLR 3680 FLKNIILPVY 3690 DKSLWDFLKL 3700 DVTTSIGRRQ 3710 HLRVSTAFVY 3720 TKNPNGYSFS 3730 IPVKVLADKF 3740 IIPGLKLNDL 3750 NSVLVMPTFH 3760 VPFTDLQVPS 3770 CKLDFREIQI 3780 YKKLRTSSFA 3790 LNLPTLPEVK 3800 FPEVDVLTKY 3810 SQPEDSLIPF 3820 FEITVPESQL 3830 TVSQFTLPKS 3840 VSDGIAALDL 3850 NAVANKIADF 3860 ELPTIIVPEQ 3870 TIEIPSIKFS 3880 VPAGIVIPSF 3890 QALTARFEVD 3900 SPVYNATWSA 3910 SLKNKADYVE 3920 TVLDSTCSST 3930 VQFLEYELNV 3940 LGTHKIEDGT 3950 LASKTKGTFA 3960 HRDFSAEYEE 3970 DGKYEGLQEW 3980 EGKAHLNIKS 3990 PAFTDLHLRY 4000 QKDKKGISTS 4010 AASPAVGTVG 4020 MDMDEDDDFS 4030 KWNFYYSPQS 4040 SPDKKLTIFK 4050 TELRVRESDE 4060 ETQIKVNWEE 4070 EAASGLLTSL 4080 KDNVPKATGV 4090 LYDYVNKYHW 4100 EHTGLTLREV 4110 SSKLRRNLQN 4120 NAEWVYQGAI 4130 RQIDDIDVRF 4140 QKAASGTTGT 4150 YQEWKDKAQN 4160 LYQELLTQEG 4170 QASFQGLKDN 4180 VFDGLVRVTQ 4190 EFHMKVKHLI 4200 DSLIDFLNFP 4210 RFQFPGKPGI 4220 YTREELCTMF 4230 IREVGTVLSQ 4240 VYSKVHNGSE 4250 ILFSYFQDLV 4260 ITLPFELRKH 4270 KLIDVISMYR 4280 ELLKDLSKEA 4290 QEVFKAIQSL 4300 KTTEVLRNLQ 4310 DLLQFIFQLI 4320 EDNIKQLKEM 4330 KFTYLINYIQ 4340 DEINTIFSDY 4350 IPYVFKLLKE 4360 NLCLNLHKFN 4370 EFIQNELQEA 4380 SQELQQIHQY 4390 IMALREEYFD 4400 PSIVGWTVKY 4410 YELEEKIVSL 4420 IKNLLVALKD 4430 FHSEYIVSAS 4440 NFTSQLSSQV 4450 EQFLHRNIQE 4460 YLSILTDPDG 4470 KGKEKIAELS 4480 ATAQEIIKSQ 4490 AIATKKIISD 4500 YHQQFRYKLQ 4510 DFSDQLSDYY 4520 EKFIAESKRL 4530 IDLSIQNYHT 4540 FLIYITELLK 4550 KLQSTTVMNP 4560 YMKLAPGELT IIL

Gene Ontology

Classification GO ID Description
Biological Process GO:0009615 response to virus
Cellular Component GO:0042627 chylomicron
Cellular Component GO:0034360 chylomicron remnant
Cellular Component GO:0030669 clathrin-coated endocytic vesicle membrane
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005769 early endosome
Cellular Component GO:0071682 endocytic vesicle lumen
Cellular Component GO:0070971 endoplasmic reticulum exit site
Cellular Component GO:0005788 endoplasmic reticulum lumen
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0031904 endosome lumen
Cellular Component GO:0010008 endosome membrane
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0034363 intermediate-density lipoprotein particle
Cellular Component GO:0043231 intracellular membrane-bounded organelle
Cellular Component GO:0005811 lipid droplet
Cellular Component GO:0034362 low-density lipoprotein particle
Cellular Component GO:0043202 lysosomal lumen
Cellular Component GO:0034359 mature chylomicron
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0005790 smooth endoplasmic reticulum
Cellular Component GO:0034361 very-low-density lipoprotein particle
Molecular Function GO:0120020 cholesterol transfer activity
Molecular Function GO:0008201 heparin binding
Molecular Function GO:0035473 lipase binding
Molecular Function GO:0050750 low-density lipoprotein particle receptor binding
Molecular Function GO:0005543 phospholipid binding
Molecular Function GO:0048018 receptor ligand activity
Biological Process GO:0071402 cellular response to lipoprotein particle stimulus
Biological Process GO:0042632 cholesterol homeostasis
Biological Process GO:0008203 cholesterol metabolic process
Biological Process GO:0030301 cholesterol transport
Biological Process GO:0042953 lipoprotein transport
Biological Process GO:0034383 low-density lipoprotein particle clearance
Biological Process GO:0034374 low-density lipoprotein particle remodeling
Biological Process GO:0010886 positive regulation of cholesterol storage
Biological Process GO:0010884 positive regulation of lipid storage
Biological Process GO:0010744 positive regulation of macrophage derived foam cell differentiation
Biological Process GO:0006642 triglyceride mobilization
Biological Process GO:0034379 very-low-density lipoprotein particle assembly

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.