Search Results
Overview
| Uniprot ID | P04150 |
|---|---|
| Protein Name | Glucocorticoid receptor |
| Gene Name | NR3C1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 57 | VASQSDSKQRRLLVD |
Function
Receptor for glucocorticoids (GC) (PubMed:27120390, PubMed:37478846). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:28139699). Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity)
Protein Sequence
10
MDSKESLTPG
20
REENPSSVLA
30
QERGDVMDFY
40
KTLRGGATVK
50
VSASSPSLAV
60
ASQSDSKQRR
70
LLVDFPKGSV
80
SNAQQPDLSK
90
AVSLSMGLYM
100
GETETKVMGN
110
DLGFPQQGQI
120
SLSSGETDLK
130
LLEESIANLN
140
RSTSVPENPK
150
SSASTAVSAA
160
PTEKEFPKTH
170
SDVSSEQQHL
180
KGQTGTNGGN
190
VKLYTTDQST
200
FDILQDLEFS
210
SGSPGKETNE
220
SPWRSDLLID
230
ENCLLSPLAG
240
EDDSFLLEGN
250
SNEDCKPLIL
260
PDTKPKIKDN
270
GDLVLSSPSN
280
VTLPQVKTEK
290
EDFIELCTPG
300
VIKQEKLGTV
310
YCQASFPGAN
320
IIGNKMSAIS
330
VHGVSTSGGQ
340
MYHYDMNTAS
350
LSQQQDQKPI
360
FNVIPPIPVG
370
SENWNRCQGS
380
GDDNLTSLGT
390
LNFPGRTVFS
400
NGYSSPSMRP
410
DVSSPPSSSS
420
TATTGPPPKL
430
CLVCSDEASG
440
CHYGVLTCGS
450
CKVFFKRAVE
460
GQHNYLCAGR
470
NDCIIDKIRR
480
KNCPACRYRK
490
CLQAGMNLEA
500
RKTKKKIKGI
510
QQATTGVSQE
520
TSENPGNKTI
530
VPATLPQLTP
540
TLVSLLEVIE
550
PEVLYAGYDS
560
SVPDSTWRIM
570
TTLNMLGGRQ
580
VIAAVKWAKA
590
IPGFRNLHLD
600
DQMTLLQYSW
610
MFLMAFALGW
620
RSYRQSSANL
630
LCFAPDLIIN
640
EQRMTLPCMY
650
DQCKHMLYVS
660
SELHRLQVSY
670
EEYLCMKTLL
680
LLSSVPKDGL
690
KSQELFDEIR
700
MTYIKELGKA
710
IVKREGNSSQ
720
NWQRFYQLTK
730
LLDSMHEVVE
740
NLLNYCFQTF
750
LDKTMSIEFP
760
EMLAEIITNQ
770
IPKYSNGNIK
KLLFHQK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0000785 | chromatin |
| Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function | GO:0003700 | DNA-binding transcription factor activity |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| Molecular Function | GO:0034056 | estrogen response element binding |
| Molecular Function | GO:0051879 | Hsp90 protein binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0004883 | nuclear glucocorticoid receptor activity |
| Molecular Function | GO:0004879 | nuclear receptor activity |
| Molecular Function | GO:1990841 | promoter-specific chromatin binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| Molecular Function | GO:1990837 | sequence-specific double-stranded DNA binding |
| Molecular Function | GO:0005496 | steroid binding |
| Molecular Function | GO:1990239 | steroid hormone binding |
| Molecular Function | GO:0017025 | TBP-class protein binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0048708 | astrocyte differentiation |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0071549 | cellular response to dexamethasone stimulus |
| Biological Process | GO:0071385 | cellular response to glucocorticoid stimulus |
| Biological Process | GO:0071383 | cellular response to steroid hormone stimulus |
| Biological Process | GO:0071560 | cellular response to transforming growth factor beta stimulus |
| Biological Process | GO:0006325 | chromatin organization |
| Biological Process | GO:0007059 | chromosome segregation |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0014004 | microglia differentiation |
| Biological Process | GO:0061744 | motor behavior |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0150076 | neuroinflammatory response |
| Biological Process | GO:0030518 | nuclear receptor-mediated steroid hormone signaling pathway |
| Biological Process | GO:1902895 | positive regulation of miRNA transcription |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0035249 | synaptic transmission, glutamatergic |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0005819 | spindle |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0001046 | core promoter sequence-specific DNA binding |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.