Search Results
Overview
| Uniprot ID | P04179 |
|---|---|
| Protein Name | Superoxide dismutase [Mn], mitochondrial |
| Gene Name | SOD2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 114 | PNGGGEPKGELLEAI |
| 122 | GELLEAIKRDFGSFD |
| 130 | RDFGSFDKFKEKLTA |
| 68 | NLNVTEEKYQEALAK |
| 75 | KYQEALAKGDVTAQI |
Function
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0070062 | extracellular exosome |
| Biological Process | GO:0030335 | positive regulation of cell migration |
| Biological Process | GO:0010729 | positive regulation of hydrogen peroxide biosynthetic process |
| Biological Process | GO:1905461 | positive regulation of vascular associated smooth muscle cell apoptotic process |
| Biological Process | GO:1905932 | positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching |
| Biological Process | GO:0051289 | protein homotetramerization |
| Biological Process | GO:0008217 | regulation of blood pressure |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0001836 | release of cytochrome c from mitochondria |
| Biological Process | GO:0019430 | removal of superoxide radicals |
| Biological Process | GO:0014823 | response to activity |
| Biological Process | GO:0046686 | response to cadmium ion |
| Biological Process | GO:0051602 | response to electrical stimulus |
| Biological Process | GO:0042542 | response to hydrogen peroxide |
| Biological Process | GO:0001666 | response to hypoxia |
| Biological Process | GO:0035902 | response to immobilization stress |
| Biological Process | GO:0035900 | response to isolation stress |
| Biological Process | GO:0033591 | response to L-ascorbic acid |
| Biological Process | GO:0032496 | response to lipopolysaccharide |
| Biological Process | GO:0071000 | response to magnetism |
| Biological Process | GO:0010042 | response to manganese ion |
| Biological Process | GO:0010269 | response to selenium ion |
| Biological Process | GO:0034021 | response to silicon dioxide |
| Biological Process | GO:0000303 | response to superoxide |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0010043 | response to zinc ion |
| Biological Process | GO:0006801 | superoxide metabolic process |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0042645 | mitochondrial nucleoid |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0030145 | manganese ion binding |
| Molecular Function | GO:0019825 | oxygen binding |
| Molecular Function | GO:0004784 | superoxide dismutase activity |
| Biological Process | GO:0003069 | acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure |
| Biological Process | GO:0071361 | cellular response to ethanol |
| Biological Process | GO:0034599 | cellular response to oxidative stress |
| Biological Process | GO:0050665 | hydrogen peroxide biosynthetic process |
| Biological Process | GO:0032364 | intracellular oxygen homeostasis |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:1902631 | negative regulation of membrane hyperpolarization |
| Biological Process | GO:0043524 | negative regulation of neuron apoptotic process |
| Biological Process | GO:1902176 | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
| Biological Process | GO:1904706 | negative regulation of vascular associated smooth muscle cell proliferation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.
[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.
[5] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.