Search Results
Overview
| Uniprot ID | P04181 |
|---|---|
| Protein Name | Ornithine aminotransferase, mitochondrial |
| Gene Name | OAT |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 107 | ALKSQVDKLTLTSRA |
| 32 | ATSVATKKTVQGPPT |
| 374 | VVTAVRGKGLLNAIV |
Function
Catalyzes the reversible interconversion of L-ornithine and 2-oxoglutarate to L-glutamate semialdehyde and L-glutamate
Protein Sequence
10
MFSKLAHLQR
20
FAVLSRGVHS
30
SVASATSVAT
40
KKTVQGPPTS
50
DDIFEREYKY
60
GAHNYHPLPV
70
ALERGKGIYL
80
WDVEGRKYFD
90
FLSSYSAVNQ
100
GHCHPKIVNA
110
LKSQVDKLTL
120
TSRAFYNNVL
130
GEYEEYITKL
140
FNYHKVLPMN
150
TGVEAGETAC
160
KLARKWGYTV
170
KGIQKYKAKI
180
VFAAGNFWGR
190
TLSAISSSTD
200
PTSYDGFGPF
210
MPGFDIIPYN
220
DLPALERALQ
230
DPNVAAFMVE
240
PIQGEAGVVV
250
PDPGYLMGVR
260
ELCTRHQVLF
270
IADEIQTGLA
280
RTGRWLAVDY
290
ENVRPDIVLL
300
GKALSGGLYP
310
VSAVLCDDDI
320
MLTIKPGEHG
330
STYGGNPLGC
340
RVAIAALEVL
350
EEENLAENAD
360
KLGIILRNEL
370
MKLPSDVVTA
380
VRGKGLLNAI
390
VIKETKDWDA
400
WKVCLRLRDN
410
GLLAKPTHGD
420
IIRFAPPLVI
430
KEDELRESIE
IINKTILSF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0004587 | ornithine aminotransferase activity |
| Molecular Function | GO:0030170 | pyridoxal phosphate binding |
| Biological Process | GO:0019544 | L-arginine catabolic process to L-glutamate |
| Biological Process | GO:0010121 | L-arginine catabolic process to proline via ornithine |
| Biological Process | GO:0055129 | L-proline biosynthetic process |
| Biological Process | GO:0007601 | visual perception |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.