Search Results
Overview
| Uniprot ID | P04182 |
|---|---|
| Protein Name | Ornithine aminotransferase, mitochondrial |
| Gene Name | Oat |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 107 | AMKSQVDKLTLTSRA |
| 374 | VVTAVRGKGLLNAIV |
| 386 | AIVIRETKDCDAWKV |
Function
Catalyzes the reversible interconversion of L-ornithine and 2-oxoglutarate to L-glutamate semialdehyde and L-glutamate
Protein Sequence
10
MLSKLASLQT
20
VAALRRGLRT
30
SVASATSVAT
40
KKTEQGPPSS
50
EYIFERESKY
60
GAHNYHPLPV
70
ALERGKGIYM
80
WDVEGRQYFD
90
FLSAYGAVSQ
100
GHCHPKIIEA
110
MKSQVDKLTL
120
TSRAFYNNVL
130
GEYEEYITKL
140
FNYNKVLPMN
150
TGVEAGETAC
160
KLARRWGYTV
170
KGIQKYKAKI
180
VFAVGNFWGR
190
TLSAVSSSTD
200
PTSYDGFGPF
210
MPGFETIPYN
220
DLPALERALQ
230
DPNVAAFMVE
240
PIQGEAGVIV
250
PDPGYLTGVR
260
ELCTRHQVLF
270
IADEIQTGLA
280
RTGRWLAVDH
290
ENVRPDIVLL
300
GKALSGGLYP
310
VSAVLCDDDI
320
MLTIKPGEHG
330
STYGGNPLGC
340
RIAIAALEVL
350
EEEHLAENAD
360
KMGAILRKEL
370
MKLPSDVVTA
380
VRGKGLLNAI
390
VIRETKDCDA
400
WKVCLRLRDN
410
GLLAKPTHGD
420
IIRLAPPLVI
430
KEDEIRESVE
IINKTILSF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0003992 | N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity |
| Molecular Function | GO:0004587 | ornithine aminotransferase activity |
| Molecular Function | GO:0030170 | pyridoxal phosphate binding |
| Biological Process | GO:0019544 | L-arginine catabolic process to L-glutamate |
| Biological Process | GO:0010121 | L-arginine catabolic process to proline via ornithine |
| Biological Process | GO:0055129 | L-proline biosynthetic process |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.