Overview
| Uniprot ID | P04185 |
|---|
| Protein Name | Urokinase-type plasminogen activator |
|---|
| Gene Name | PLAU |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 296 |
LLKIRTDKGQCAQPS |
Function
Serine protease that cleaves the inactive precursor plasminogen at a specific Arg-Val peptide bond, converting it into active plasmin. Secreted as an inactive zymogen, it is recruited and activated at the cell surface through interaction with the urokinase plasminogen activator receptor (uPAR). Cell-surface activation enables localized, plasmin-dependent pericellular proteolysis, regulating extracellular matrix degradation in cell migration and tissue remodeling (By similarity). Also contributes to fibrinolysis and blood clot clearance by promoting plasmin generation (By similarity)
Protein Sequence
10
MRVLRACLSL
20
CVLVVSDSKG
30
SHELHQESGA
40
SNCGCLNGGK
50
CVSYKYFSNI
60
QRCSCPKKFQ
70
GEHCEIDTSQ
80
TCFEGNGHSY
90
RGKANTNTGG
100
RPCLPWNSAT
110
VLLNTYHAHR
120
PDALQLGLGK
130
HNYCRNPDNQ
140
RRPWCYVQVG
150
LKQLVQECMV
160
PNCSGGESHR
170
PAYDGKNPFS
180
TPEKVEFQCG
190
QKALRPRFKI
200
VGGKSTTIEN
210
QPWFAAIYRR
220
HRGGSVTYVC
230
GGSLISPCWV
240
VSATHCFINY
250
QQKEDYIVYL
260
GRQTLHSSTH
270
GEMKFEVEKL
280
ILHEDYSADS
290
LAHHNDIALL
300
KIRTDKGQCA
310
QPSRSIQTIC
320
LPPVNGDAHF
330
GASCEIVGFG
340
KEDPSDYLYP
350
EQLKMTVVKL
360
VSHRECQQPH
370
YYGSEVTTKM
380
LCAADPQWKT
390
DSCQGDSGGP
400
LVCSTQGRLT
410
LTGIVSWGRE
420
CAMKDKPGVY
430
TRVSRFLTWI
440
HTHVGGENGL
AH
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005615 |
extracellular space |
| Molecular Function |
GO:0004252 |
serine-type endopeptidase activity |
| Biological Process |
GO:0042730 |
fibrinolysis |
| Biological Process |
GO:0031639 |
plasminogen activation |
| Biological Process |
GO:0033628 |
regulation of cell adhesion mediated by integrin |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.