Search Results
Overview
| Uniprot ID | P04233 |
|---|---|
| Protein Name | HLA class II histocompatibility antigen gamma chain |
| Gene Name | CD74 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 170 | PENLRHLKNTMETID |
| 43 | RPGAPESKCSRGALY |
Function
Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF
Protein Sequence
10
MHRRRSRSCR
20
EDQKPVMDDQ
30
RDLISNNEQL
40
PMLGRRPGAP
50
ESKCSRGALY
60
TGFSILVTLL
70
LAGQATTAYF
80
LYQQQGRLDK
90
LTVTSQNLQL
100
ENLRMKLPKP
110
PKPVSKMRMA
120
TPLLMQALPM
130
GALPQGPMQN
140
ATKYGNMTED
150
HVMHLLQNAD
160
PLKVYPPLKG
170
SFPENLRHLK
180
NTMETIDWKV
190
FESWMHHWLL
200
FEMSRHSLEQ
210
KPTDAPPKVL
220
TKCQEEVSHI
230
PAVHPGSFRP
240
KCDENGNYLP
250
LQCYGSIGYC
260
WCVFPNGTEV
270
PNTRSRGHHN
280
CSESLELEDP
290
SSGLGVTKQD
LGPVPM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0030669 | clathrin-coated endocytic vesicle membrane |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0030666 | endocytic vesicle membrane |
| Cellular Component | GO:0012507 | ER to Golgi transport vesicle membrane |
| Cellular Component | GO:0009897 | external side of plasma membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0005770 | late endosome |
| Cellular Component | GO:0098553 | lumenal side of endoplasmic reticulum membrane |
| Cellular Component | GO:0043202 | lysosomal lumen |
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0035692 | macrophage migration inhibitory factor receptor complex |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0042613 | MHC class II protein complex |
| Cellular Component | GO:0005771 | multivesicular body |
| Cellular Component | GO:0035693 | NOS2-CD74 complex |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0032588 | trans-Golgi network membrane |
| Cellular Component | GO:0030658 | transport vesicle membrane |
| Cellular Component | GO:0005773 | vacuole |
| Molecular Function | GO:0001540 | amyloid-beta binding |
| Molecular Function | GO:0042609 | CD4 receptor binding |
| Molecular Function | GO:0019955 | cytokine binding |
| Molecular Function | GO:0004896 | cytokine receptor activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0035718 | macrophage migration inhibitory factor binding |
| Molecular Function | GO:0042289 | MHC class II protein binding |
| Molecular Function | GO:0042658 | MHC class II protein binding, via antigen binding groove |
| Molecular Function | GO:0023026 | MHC class II protein complex binding |
| Molecular Function | GO:0050998 | nitric-oxide synthase binding |
| Molecular Function | GO:0044183 | protein folding chaperone |
| Biological Process | GO:0019882 | antigen processing and presentation |
| Biological Process | GO:0019883 | antigen processing and presentation of endogenous antigen |
| Biological Process | GO:0046597 | host-mediated suppression of symbiont invasion |
| Biological Process | GO:0016064 | immunoglobulin mediated immune response |
| Biological Process | GO:0006886 | intracellular protein transport |
| Biological Process | GO:0035691 | macrophage migration inhibitory factor signaling pathway |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0030336 | negative regulation of cell migration |
| Biological Process | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator |
| Biological Process | GO:1902166 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| Biological Process | GO:0002906 | negative regulation of mature B cell apoptotic process |
| Biological Process | GO:0002792 | negative regulation of peptide secretion |
| Biological Process | GO:0030890 | positive regulation of B cell proliferation |
| Biological Process | GO:0043123 | positive regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:2000343 | positive regulation of chemokine (C-X-C motif) ligand 2 production |
| Biological Process | GO:0032722 | positive regulation of chemokine production |
| Biological Process | GO:0001961 | positive regulation of cytokine-mediated signaling pathway |
| Biological Process | GO:0002606 | positive regulation of dendritic cell antigen processing and presentation |
| Biological Process | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:0048146 | positive regulation of fibroblast proliferation |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0032755 | positive regulation of interleukin-6 production |
| Biological Process | GO:0032757 | positive regulation of interleukin-8 production |
| Biological Process | GO:0060907 | positive regulation of macrophage cytokine production |
| Biological Process | GO:2000448 | positive regulation of macrophage migration inhibitory factor signaling pathway |
| Biological Process | GO:0045657 | positive regulation of monocyte differentiation |
| Biological Process | GO:0090023 | positive regulation of neutrophil chemotaxis |
| Biological Process | GO:0031394 | positive regulation of prostaglandin biosynthetic process |
| Biological Process | GO:0002830 | positive regulation of type 2 immune response |
| Biological Process | GO:0001516 | prostaglandin biosynthetic process |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0070206 | protein trimerization |
| Biological Process | GO:0065003 | protein-containing complex assembly |
| Biological Process | GO:0043030 | regulation of macrophage activation |
| Biological Process | GO:0034341 | response to type II interferon |
| Biological Process | GO:0002286 | T cell activation involved in immune response |
| Biological Process | GO:0045058 | T cell selection |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.