Search Results
Overview
| Uniprot ID | P04247 |
|---|---|
| Protein Name | Myoglobin |
| Gene Name | Mb |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 146 | FRNDIAAKYKELGFQ |
| 148 | NDIAAKYKELGFQG* |
| 35 | EVLIGLFKTHPETLD |
| 43 | THPETLDKFDKFKNL |
| 46 | ETLDKFDKFKNLKSE |
| 51 | FDKFKNLKSEEDMKG |
| 57 | LKSEEDMKGSEDLKK |
| 64 | KGSEDLKKHGCTVLT |
| 78 | TALGTILKKKGQHAA |
| 80 | LGTILKKKGQHAAEI |
| 97 | LAQSHATKHKIPVKY |
Function
Monomeric heme protein which primary function is to store oxygen and facilitate its diffusion within muscle tissues. Reversibly binds oxygen through a pentacoordinated heme iron and enables its timely and efficient release as needed during periods of heightened demand (PubMed:10468637, PubMed:11304494). Depending on the oxidative conditions of tissues and cells, and in addition to its ability to bind oxygen, it also has a nitrite reductase activity whereby it regulates the production of bioactive nitric oxide (By similarity). Under stress conditions, like hypoxia and anoxia, it also protects cells against reactive oxygen species thanks to its pseudoperoxidase activity (PubMed:15132981)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0016528 | sarcoplasm |
| Molecular Function | GO:0020037 | heme binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0098809 | nitrite reductase activity |
| Molecular Function | GO:0019825 | oxygen binding |
| Molecular Function | GO:0005344 | oxygen carrier activity |
| Molecular Function | GO:0004601 | peroxidase activity |
| Biological Process | GO:0050873 | brown fat cell differentiation |
| Biological Process | GO:0071732 | cellular response to nitric oxide |
| Biological Process | GO:0009631 | cold acclimation |
| Biological Process | GO:0043353 | enucleate erythrocyte differentiation |
| Biological Process | GO:0007507 | heart development |
| Biological Process | GO:0015671 | oxygen transport |
| Biological Process | GO:0019430 | removal of superoxide radicals |
| Biological Process | GO:0001975 | response to amphetamine |
| Biological Process | GO:0009725 | response to hormone |
| Biological Process | GO:0042542 | response to hydrogen peroxide |
| Biological Process | GO:0001666 | response to hypoxia |
| Biological Process | GO:0002931 | response to ischemia |
| Biological Process | GO:0014850 | response to muscle activity |
| Biological Process | GO:0080033 | response to nitrite |
| Biological Process | GO:0097066 | response to thyroid hormone |
| Biological Process | GO:0003009 | skeletal muscle contraction |
| Biological Process | GO:0031444 | slow-twitch skeletal muscle fiber contraction |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.
[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.