Search Results
Overview
| Uniprot ID | P04256 |
|---|---|
| Protein Name | Heterogeneous nuclear ribonucleoprotein A1 |
| Gene Name | Hnrnpa1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 298 | GGGQYFAKPRNQGGY |
| 8 | MSKSESPKEPEQLRK |
Function
Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform. Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1. May bind to specific miRNA hairpins
Protein Sequence
10
MSKSESPKEP
20
EQLRKLFIGG
30
LSFETTDESL
40
RSHFEQWGTL
50
TDCVVMRDPN
60
TKRSRGFGFV
70
TYATVEEVDA
80
AMNARPHKVD
90
GRVVEPKRAV
100
SREDSQRPGA
110
HLTVKKIFVG
120
GIKEDTEEHH
130
LRDYFEQYGK
140
IEVIEIMTDR
150
GSGKKRGFAF
160
VTFDDHDSVD
170
KIVIQKYHTV
180
NGHNCEVRKA
190
LCKQEMASAS
200
SSQRGRSGSG
210
NFGGGRGGGF
220
GGNDNFGRGG
230
NFSGRGGFGG
240
SRGGGGYGGS
250
GDGYNGFGND
260
GSNFGGGGSY
270
NDFGNYNNQS
280
SNFGPMKGGN
290
FGGRSSGPYG
300
GGGQYFAKPR
310
NQGGYGGSSS
320
SSSYGSGRRF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0071013 | catalytic step 2 spliceosome |
| Biological Process | GO:0032212 | positive regulation of telomere maintenance via telomerase |
| Biological Process | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome |
| Biological Process | GO:0043484 | regulation of RNA splicing |
| Biological Process | GO:0034976 | response to endoplasmic reticulum stress |
| Biological Process | GO:0016070 | RNA metabolic process |
| Biological Process | GO:0008380 | RNA splicing |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:1990826 | nucleoplasmic periphery of the nuclear pore complex |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| Cellular Component | GO:0005681 | spliceosomal complex |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:1990814 | DNA/DNA annealing activity |
| Molecular Function | GO:0098505 | G-rich strand telomeric DNA binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0035198 | miRNA binding |
| Molecular Function | GO:0003730 | mRNA 3'-UTR binding |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0036002 | pre-mRNA binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0033592 | RNA strand annealing activity |
| Molecular Function | GO:1990825 | sequence-specific mRNA binding |
| Molecular Function | GO:0003697 | single-stranded DNA binding |
| Molecular Function | GO:0003727 | single-stranded RNA binding |
| Molecular Function | GO:0061752 | telomeric repeat-containing RNA binding |
| Biological Process | GO:0000380 | alternative mRNA splicing, via spliceosome |
| Biological Process | GO:0071364 | cellular response to epidermal growth factor stimulus |
| Biological Process | GO:0042149 | cellular response to glucose starvation |
| Biological Process | GO:0035865 | cellular response to potassium ion |
| Biological Process | GO:1903936 | cellular response to sodium arsenite |
| Biological Process | GO:0051170 | import into nucleus |
| Biological Process | GO:0030324 | lung development |
| Biological Process | GO:0008584 | male gonad development |
| Biological Process | GO:0000398 | mRNA splicing, via spliceosome |
| Biological Process | GO:0051028 | mRNA transport |
| Biological Process | GO:0032211 | negative regulation of telomere maintenance via telomerase |
| Biological Process | GO:0051168 | nuclear export |
| Biological Process | GO:0045760 | positive regulation of action potential |
| Biological Process | GO:0010628 | positive regulation of gene expression |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.