Search Results

Overview

Uniprot IDP04264
Protein NameKeratin, type II cytoskeletal 1
Gene NameKRT1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
185 SREREQIKSLNNQFA
197 QFASFIDKVRFLEQQ
211 QNQVLQTKWELLQQV
246 RRRVDQLKSDQSRLD
257 SRLDSELKNMQDMVE
288 ENEFVTIKKDVDGAY
289 NEFVTIKKDVDGAYM
355 DSIIAEVKAQYEDIA
364 QYEDIAQKSKAEAES
366 EDIAQKSKAEAESLY
376 AESLYQSKYEELQIT
395 GDSVRNSKIEISELN
416 RSEIDNVKKQISNLQ
417 SEIDNVKKQISNLQQ
438 QRGENALKDAKNKLN
455 EDALQQAKEDLARLL

Function

Structural component of intermediate filaments in suprabasal keratinocytes of stratified epithelia. Forms heteropolymers with a type I keratin, assembling into keratin intermediate filament networks that provide mechanical strength and structural stability to differentiating epidermal cells (PubMed:1381288). May regulate the activity of kinases such as PKC and SRC by interacting with integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1) (PubMed:17956333, PubMed:21544310). In complex with C1QBP, acts as a high-affinity receptor for kininogen-1 (HMWK) (PubMed:21544310)

Protein Sequence

10 MSRQFSSRSG 20 YRSGGGFSSG 30 SAGIINYQRR 40 TTSSSTRRSG 50 GGGGRFSSCG 60 GGGGSFGAGG 70 GFGSRSLVNL 80 GGSKSISISV 90 ARGGGRGSGF 100 GGGYGGGGFG 110 GGGFGGGGFG 120 GGGIGGGGFG 130 GFGSGGGGFG 140 GGGFGGGGYG 150 GGYGPVCPPG 160 GIQEVTINQS 170 LLQPLNVEID 180 PEIQKVKSRE 190 REQIKSLNNQ 200 FASFIDKVRF 210 LEQQNQVLQT 220 KWELLQQVDT 230 STRTHNLEPY 240 FESFINNLRR 250 RVDQLKSDQS 260 RLDSELKNMQ 270 DMVEDYRNKY 280 EDEINKRTNA 290 ENEFVTIKKD 300 VDGAYMTKVD 310 LQAKLDNLQQ 320 EIDFLTALYQ 330 AELSQMQTQI 340 SETNVILSMD 350 NNRSLDLDSI 360 IAEVKAQYED 370 IAQKSKAEAE 380 SLYQSKYEEL 390 QITAGRHGDS 400 VRNSKIEISE 410 LNRVIQRLRS 420 EIDNVKKQIS 430 NLQQSISDAE 440 QRGENALKDA 450 KNKLNDLEDA 460 LQQAKEDLAR 470 LLRDYQELMN 480 TKLALDLEIA 490 TYRTLLEGEE 500 SRMSGECAPN 510 VSVSVSTSHT 520 TISGGGSRGG 530 GGGGYGSGGS 540 SYGSGGGSYG 550 SGGGGGGGRG 560 SYGSGGSSYG 570 SGGGSYGSGG 580 GGGGHGSYGS 590 GSSSGGYRGG 600 SGGGGGGSSG 610 GRGSGGGSSG 620 GSIGGRGSSS 630 GGVKSSGGSS 640 SVKFVSTTYS GVTR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0072562 blood microparticle
Cellular Component GO:0001533 cornified envelope
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:1904813 ficolin-1-rich granule lumen
Cellular Component GO:0045095 keratin filament
Cellular Component GO:0016020 membrane
Cellular Component GO:0005634 nucleus
Molecular Function GO:0030246 carbohydrate binding
Molecular Function GO:0046982 protein heterodimerization activity
Molecular Function GO:0038023 signaling receptor activity
Molecular Function GO:0030280 structural constituent of skin epidermis
Biological Process GO:0001867 complement activation, lectin pathway
Biological Process GO:0070268 cornification
Biological Process GO:0042730 fibrinolysis
Biological Process GO:0045109 intermediate filament organization
Biological Process GO:0031424 keratinization
Biological Process GO:0051290 protein heterotetramerization
Biological Process GO:0045765 regulation of angiogenesis
Biological Process GO:0006979 response to oxidative stress

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.

[4] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.