Search Results
Overview
| Uniprot ID | P04439 |
|---|---|
| Protein Name | HLA class I histocompatibility antigen, A alpha chain |
| Gene Name | HLA-A |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 200 | RRYLENGKETLQRTD |
| 92 | DQETRNVKAQSQTDR |
Function
Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-A-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:10449296, PubMed:12138174, PubMed:12393434, PubMed:1402688, PubMed:15893615, PubMed:17189421, PubMed:19543285, PubMed:21498667, PubMed:24192765, PubMed:24395804, PubMed:2456340, PubMed:2784196, PubMed:28250417, PubMed:7504010, PubMed:7694806, PubMed:9862734). May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:25880248, PubMed:7506728, PubMed:7679507). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (PubMed:12796775, PubMed:18275829, PubMed:19542454, PubMed:28250417). Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome or via endopeptidase IDE/insulin-degrading enzyme (PubMed:17079320, PubMed:17189421, PubMed:20364150, PubMed:26929325, PubMed:27049119). Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9 (PubMed:7504010, PubMed:9862734)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0031901 | early endosome membrane |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0070971 | endoplasmic reticulum exit site |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0012507 | ER to Golgi transport vesicle membrane |
| Cellular Component | GO:0009897 | external side of plasma membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0005797 | Golgi medial cisterna |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0098553 | lumenal side of endoplasmic reticulum membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0042824 | MHC class I peptide loading complex |
| Cellular Component | GO:0042612 | MHC class I protein complex |
| Cellular Component | GO:0030670 | phagocytic vesicle membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0055038 | recycling endosome membrane |
| Molecular Function | GO:0030881 | beta-2-microglobulin binding |
| Molecular Function | GO:0042610 | CD8 receptor binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0042605 | peptide antigen binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Molecular Function | GO:0042608 | T cell receptor binding |
| Molecular Function | GO:0046977 | TAP binding |
| Molecular Function | GO:0062061 | TAP complex binding |
| Biological Process | GO:0019731 | antibacterial humoral response |
| Biological Process | GO:0019885 | antigen processing and presentation of endogenous peptide antigen via MHC class I |
| Biological Process | GO:0002485 | antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent |
| Biological Process | GO:0002486 | antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent |
| Biological Process | GO:0002476 | antigen processing and presentation of endogenous peptide antigen via MHC class Ib |
| Biological Process | GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I |
| Biological Process | GO:0002477 | antigen processing and presentation of exogenous peptide antigen via MHC class Ib |
| Biological Process | GO:0036037 | CD8-positive, alpha-beta T cell activation |
| Biological Process | GO:0050830 | defense response to Gram-positive bacterium |
| Biological Process | GO:0016045 | detection of bacterium |
| Biological Process | GO:0006955 | immune response |
| Biological Process | GO:0045087 | innate immune response |
| Biological Process | GO:0002502 | peptide antigen assembly with MHC class I protein complex |
| Biological Process | GO:2001187 | positive regulation of CD8-positive, alpha-beta T cell activation |
| Biological Process | GO:2000566 | positive regulation of CD8-positive, alpha-beta T cell proliferation |
| Biological Process | GO:2000568 | positive regulation of memory T cell activation |
| Biological Process | GO:0002726 | positive regulation of T cell cytokine production |
| Biological Process | GO:0001916 | positive regulation of T cell mediated cytotoxicity |
| Biological Process | GO:0032729 | positive regulation of type II interferon production |
| Biological Process | GO:0042270 | protection from natural killer cell mediated cytotoxicity |
| Biological Process | GO:0002715 | regulation of natural killer cell mediated immunity |
| Biological Process | GO:0001913 | T cell mediated cytotoxicity |
| Biological Process | GO:0002419 | T cell mediated cytotoxicity directed against tumor cell target |
| Biological Process | GO:0050852 | T cell receptor signaling pathway |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.