Search Results
Overview
| Uniprot ID | P04550 |
|---|---|
| Protein Name | Parathymosin |
| Gene Name | Ptms |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 15 | AAAELSAKDLKEKKD |
| 27 | KKDKVEEKAGRKERK |
| 92 | EEDEADPKRQKTENG |
Function
Parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistance to certain opportunistic infections
Protein Sequence
10
MSEKSVEAAA
20
ELSAKDLKEK
30
KDKVEEKAGR
40
KERKKEVVEE
50
EENGAEEEEE
60
ETAEDGEDDD
70
EGDEEDEEEE
80
EEEDEGPVRK
90
RTAEEEDEAD
100
PKRQKTENGA
SA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0004857 | enzyme inhibitor activity |
| Molecular Function | GO:0042393 | histone binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0002376 | immune system process |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.