Search Results
Overview
| Uniprot ID | P04574 |
|---|---|
| Protein Name | Calpain small subunit 1 |
| Gene Name | CAPNS1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 133 | VTRHPDLKTDGFGID |
| 170 | KYLWNNIKKWQAIYK |
| 171 | YLWNNIKKWQAIYKQ |
| 177 | KKWQAIYKQFDVDRS |
| 242 | DAMFRAFKSLDKDGT |
Function
Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Essential for embryonic development (By similarity)
Protein Sequence
10
MFLVNSFLKG
20
GGGGGGGGGG
30
LGGGLGNVLG
40
GLISGAGGGG
50
GGGGGGGGGG
60
GGGGTAMRIL
70
GGVISAISEA
80
AAQYNPEPPP
90
PRTHYSNIEA
100
NESEEVRQFR
110
RLFAQLAGDD
120
MEVSATELMN
130
ILNKVVTRHP
140
DLKTDGFGID
150
TCRSMVAVMD
160
SDTTGKLGFE
170
EFKYLWNNIK
180
KWQAIYKQFD
190
VDRSGTIGSS
200
ELPGAFEAAG
210
FHLNEHLYSM
220
IIRRYSDEGG
230
NMDFDNFISC
240
LVRLDAMFRA
250
FKSLDKDGTG
260
QIQVNIQEWL
QLTMYS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0110158 | calpain complex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity |
| Biological Process | GO:0006508 | proteolysis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.