Search Results

Overview

Uniprot ID	P04629
Protein Name	High affinity nerve growth factor receptor
Gene Name	NTRK1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
240	EQSATVMKSGGLPSL

Function

Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand (PubMed:1281417, PubMed:15488758, PubMed:17196528, PubMed:1849459, PubMed:1850821, PubMed:22649032, PubMed:27445338, PubMed:8325889). Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival (By similarity). Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:1281417). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors

Protein Sequence

10 MLRGGRRGQL 20 GWHSWAAGPG 30 SLLAWLILAS 40 AGAAPCPDAC 50 CPHGSSGLRC 60 TRDGALDSLH 70 HLPGAENLTE 80 LYIENQQHLQ 90 HLELRDLRGL 100 GELRNLTIVK 110 SGLRFVAPDA 120 FHFTPRLSRL 130 NLSFNALESL 140 SWKTVQGLSL 150 QELVLSGNPL 160 HCSCALRWLQ 170 RWEEEGLGGV 180 PEQKLQCHGQ 190 GPLAHMPNAS 200 CGVPTLKVQV 210 PNASVDVGDD 220 VLLRCQVEGR 230 GLEQAGWILT 240 ELEQSATVMK 250 SGGLPSLGLT 260 LANVTSDLNR 270 KNVTCWAEND 280 VGRAEVSVQV 290 NVSFPASVQL 300 HTAVEMHHWC 310 IPFSVDGQPA 320 PSLRWLFNGS 330 VLNETSFIFT 340 EFLEPAANET 350 VRHGCLRLNQ 360 PTHVNNGNYT 370 LLAANPFGQA 380 SASIMAAFMD 390 NPFEFNPEDP 400 IPVSFSPVDT 410 NSTSGDPVEK 420 KDETPFGVSV 430 AVGLAVFACL 440 FLSTLLLVLN 450 KCGRRNKFGI 460 NRPAVLAPED 470 GLAMSLHFMT 480 LGGSSLSPTE 490 GKGSGLQGHI 500 IENPQYFSDA 510 CVHHIKRRDI 520 VLKWELGEGA 530 FGKVFLAECH 540 NLLPEQDKML 550 VAVKALKEAS 560 ESARQDFQRE 570 AELLTMLQHQ 580 HIVRFFGVCT 590 EGRPLLMVFE 600 YMRHGDLNRF 610 LRSHGPDAKL 620 LAGGEDVAPG 630 PLGLGQLLAV 640 ASQVAAGMVY 650 LAGLHFVHRD 660 LATRNCLVGQ 670 GLVVKIGDFG 680 MSRDIYSTDY 690 YRVGGRTMLP 700 IRWMPPESIL 710 YRKFTTESDV 720 WSFGVVLWEI 730 FTYGKQPWYQ 740 LSNTEAIDCI 750 TQGRELERPR 760 ACPPEVYAIM 770 RGCWQREPQQ 780 RHSIKDVHAR 790 LQALAQAPPV YLDVLG

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0030424	axon
Cellular Component	GO:0009986	cell surface
Cellular Component	GO:0030425	dendrite
Cellular Component	GO:0005769	early endosome
Cellular Component	GO:0031901	early endosome membrane
Cellular Component	GO:0010008	endosome membrane
Cellular Component	GO:0005770	late endosome
Cellular Component	GO:0031902	late endosome membrane
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0043025	neuronal cell body
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0032991	protein-containing complex
Cellular Component	GO:0043235	receptor complex
Cellular Component	GO:0055038	recycling endosome membrane
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0005004	GPI-linked ephrin receptor activity
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0019900	kinase binding
Molecular Function	GO:0048406	nerve growth factor binding
Molecular Function	GO:0010465	nerve growth factor receptor activity
Molecular Function	GO:0043121	neurotrophin binding
Molecular Function	GO:0005166	neurotrophin p75 receptor binding
Molecular Function	GO:0005030	neurotrophin receptor activity
Molecular Function	GO:0042803	protein homodimerization activity
Molecular Function	GO:0004713	protein tyrosine kinase activity
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity
Biological Process	GO:0007411	axon guidance
Biological Process	GO:0060385	axonogenesis involved in innervation
Biological Process	GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus
Biological Process	GO:0071316	cellular response to nicotine
Biological Process	GO:0007623	circadian rhythm
Biological Process	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain
Biological Process	GO:0050965	detection of temperature stimulus involved in sensory perception of pain
Biological Process	GO:0007611	learning or memory
Biological Process	GO:0043066	negative regulation of apoptotic process
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation
Biological Process	GO:0045766	positive regulation of angiogenesis
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade
Biological Process	GO:0043547	positive regulation of GTPase activity
Biological Process	GO:0010976	positive regulation of neuron projection development
Biological Process	GO:0051897	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Process	GO:0043068	positive regulation of programmed cell death
Biological Process	GO:0046579	positive regulation of Ras protein signal transduction
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic
Biological Process	GO:0010623	programmed cell death involved in cell development
Biological Process	GO:0046777	protein autophosphorylation
Biological Process	GO:0006468	protein phosphorylation
Biological Process	GO:0048678	response to axon injury
Biological Process	GO:0051602	response to electrical stimulus
Biological Process	GO:0051599	response to hydrostatic pressure
Biological Process	GO:0031667	response to nutrient levels
Biological Process	GO:0009410	response to xenobiotic stimulus
Biological Process	GO:0060009	Sertoli cell development
Biological Process	GO:0007283	spermatogenesis
Biological Process	GO:0048485	sympathetic nervous system development
Biological Process	GO:0008285	negative regulation of cell population proliferation
Biological Process	GO:0043524	negative regulation of neuron apoptotic process
Biological Process	GO:0038180	nerve growth factor signaling pathway
Biological Process	GO:0048666	neuron development
Biological Process	GO:0031175	neuron projection development
Biological Process	GO:0048011	neurotrophin TRK receptor signaling pathway
Biological Process	GO:0021553	olfactory nerve development
Biological Process	GO:0038083	peptidyl-tyrosine autophosphorylation

Reference

[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.