Search Results
Overview
| Uniprot ID | P04632 |
|---|---|
| Protein Name | Calpain small subunit 1 |
| Gene Name | CAPNS1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 172 | KYLWNNIKRWQAIYK |
| 244 | DAMFRAFKSLDKDGT |
Function
Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Essential for embryonic development (By similarity)
Protein Sequence
10
MFLVNSFLKG
20
GGGGGGGGGG
30
LGGGLGNVLG
40
GLISGAGGGG
50
GGGGGGGGGG
60
GGGGGGTAMR
70
ILGGVISAIS
80
EAAAQYNPEP
90
PPPRTHYSNI
100
EANESEEVRQ
110
FRRLFAQLAG
120
DDMEVSATEL
130
MNILNKVVTR
140
HPDLKTDGFG
150
IDTCRSMVAV
160
MDSDTTGKLG
170
FEEFKYLWNN
180
IKRWQAIYKQ
190
FDTDRSGTIC
200
SSELPGAFEA
210
AGFHLNEHLY
220
NMIIRRYSDE
230
SGNMDFDNFI
240
SCLVRLDAMF
250
RAFKSLDKDG
260
TGQIQVNIQE
WLQLTMYS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0110158 | calpain complex |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0006508 | proteolysis |
| Biological Process | GO:0016241 | regulation of macroautophagy |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.